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Effects of Cadmium Exposure on Leydig Cells and Blood Vessels in Mouse Testis

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  • Shi-Han Yang

    (College of Resource and Environment Science, Nanjing Agricultural University, Nanjing 210095, China
    College of Veterinary Medicine, Nanjing Agricultural University, Nanjing 210095, China)

  • Si-Ting Chen

    (College of Veterinary Medicine, South China Agricultural University, Guangzhou 510642, China)

  • Chen Liang

    (College of Veterinary Medicine, South China Agricultural University, Guangzhou 510642, China)

  • Yong-Hong Shi

    (College of Veterinary Medicine, Nanjing Agricultural University, Nanjing 210095, China)

  • Qiu-Sheng Chen

    (College of Veterinary Medicine, Nanjing Agricultural University, Nanjing 210095, China)

Abstract

Environmental exposure to cadmium (Cd) contributes to a decline in the quality of human semen. Although the testis is sensitive to Cd exposure, the mechanism underlying how cadmium affects the testis remains to be defined. In this study, male mice were treated with intraperitoneal injections of 0, 0.5, 1.5 and 2.5 mg CdCl 2 /kg/day for 10 days, respectively. Both the testicular weight and the 3β-HSD activity of Leydig cells were significantly reduced with the administration of 2.5 mg CdCl 2 /kg/day. The height of endothelial cells in the interstitial blood vessels significantly increased with the use of 2.5 mg CdCl 2 /kg/day compared with the control. Western blot data showed that the protein levels of CD31, αSMA, caveolin and Ng2 increased with cadmium exposure, and this increase was particularly significant with the administration of 2.5 mg CdCl 2 /kg/day. CD31, αSMA, caveolin and Ng2 are related to angiogenesis. Based on our data, cadmium exposure may stimulate the proliferation of the mural cells and endothelial cells of blood vessels, which may lead to abnormal function of the testis.

Suggested Citation

  • Shi-Han Yang & Si-Ting Chen & Chen Liang & Yong-Hong Shi & Qiu-Sheng Chen, 2022. "Effects of Cadmium Exposure on Leydig Cells and Blood Vessels in Mouse Testis," IJERPH, MDPI, vol. 19(4), pages 1-13, February.
    • Handle: RePEc:gam:jijerp:v:19:y:2022:i:4:p:2416-:d:753525
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    References listed on IDEAS

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    1. Tariq Iqbal & Maosheng Cao & Zijiao Zhao & Yun Zhao & Lu Chen & Tong Chen & Chunjin Li & Xu Zhou, 2021. "Damage to the Testicular Structure of Rats by Acute Oral Exposure of Cadmium," IJERPH, MDPI, vol. 18(11), pages 1-13, June.
    2. Deepti L. Kumar & Tony DeFalco, 2018. "A perivascular niche for multipotent progenitors in the fetal testis," Nature Communications, Nature, vol. 9(1), pages 1-13, December.
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