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Natural Bioactive Compounds in the Management of Oral Diseases in Nephropathic Patients

Author

Listed:
  • Michele Basilicata

    (UOSD Special Care Dentistry, Department of Experimental Medicine and Surgery, University of Rome Tor Vergata, 00100 Rome, Italy)

  • Manuela Di Lauro

    (UOC of Internal Medicine-Center of Hypertension and Nephrology Unit, Department of Systems Medicine, University of Rome Tor Vergata, 00133 Rome, Italy)

  • Vincenzo Campolattano

    (UOSD Special Care Dentistry, Department of Dentistry and Dental Prosthesis, University of Rome Tor Vergata, 00133 Rome, Italy)

  • Giulia Marrone

    (UOC of Internal Medicine-Center of Hypertension and Nephrology Unit, Department of Systems Medicine, University of Rome Tor Vergata, 00133 Rome, Italy)

  • Roberto Celotto

    (Department of Cardiovascular Disease, University of Rome Tor Vergata, 00133 Rome, Italy)

  • Anna Paola Mitterhofer

    (Nephrology and Dialysis Unit, Department of Systems Medicine, University of Rome Tor Vergata, 00133 Rome, Italy)

  • Patrizio Bollero

    (UOSD Special Care Dentistry, Department of Systems Medicine, University of Rome Tor Vergata, 00100 Rome, Italy)

  • Nicola Di Daniele

    (UOC of Internal Medicine-Center of Hypertension and Nephrology Unit, Department of Systems Medicine, University of Rome Tor Vergata, 00133 Rome, Italy)

  • Annalisa Noce

    (UOC of Internal Medicine-Center of Hypertension and Nephrology Unit, Department of Systems Medicine, University of Rome Tor Vergata, 00133 Rome, Italy)

Abstract

Among the chronic non-communicable degenerative diseases (CDNCDs), chronic kidney disease (CKD) represents a global public health problem. Recent studies demonstrate a mutual cause–effect relationship between CKD and oral diseases, in which the presence of one induces the onset and faster progression of the other. In particular, the oral cavity alterations more frequent in CKD patients are: chronic periodontitis diseases, bone lesions, oral infections, and oral cancer lesions. Currently, a standardized therapy for the treatment of oral diseases is lacking. For this reason, natural bioactive compounds (NBCs), characterized by several health effects, such as antioxidant, antimicrobial, anti-inflammatory and anti-cancer actions, represent a new possible adjuvant therapy in the management of these pathological conditions. Among NBCs, polyphenols play a leading role due to positive modulation of oral microbiota, preventing and correcting oral dysbiosis. Moreover, these compounds exert anti-inflammatory effects, such as inhibiting the production of pro-inflammatory cytokines and the expression of cycloxigenase-2. In this light, the formulation of a new mouthwash/gel/gingival paste, with a high content of polyphenols in association with NBCs characterized by antimicrobial action, could represent a future therapy of oral disease in CKD patients.

Suggested Citation

  • Michele Basilicata & Manuela Di Lauro & Vincenzo Campolattano & Giulia Marrone & Roberto Celotto & Anna Paola Mitterhofer & Patrizio Bollero & Nicola Di Daniele & Annalisa Noce, 2022. "Natural Bioactive Compounds in the Management of Oral Diseases in Nephropathic Patients," IJERPH, MDPI, vol. 19(3), pages 1-16, January.
    • Handle: RePEc:gam:jijerp:v:19:y:2022:i:3:p:1665-:d:739939
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    Citations

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    Cited by:

    1. Elisa Grazioli & Eliana Tranchita & Giulia Marrone & Silvia Urciuoli & Manuela Di Lauro & Claudia Cerulli & Nicolò Piacentini & Arianna Murri & Roberto Celotto & Annalisa Romani & Attilio Parisi & Nic, 2022. "The Impact of Functional Bars and Adapted Physical Activity on Quality of Life in Chronic Kidney Disease: A Pilot Study," IJERPH, MDPI, vol. 19(6), pages 1-19, March.

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