IDEAS home Printed from https://ideas.repec.org/a/gam/jijerp/v19y2022i3p1640-d739698.html
   My bibliography  Save this article

Moderators and Other Predictors of Methylphenidate Response in Children and Adolescents with ADHD

Author

Listed:
  • Barbara D’Aiello

    (Child and Adolescent Neuropsychiatry Unit, Department of Neuroscience, Bambino Gesù Children’s Hospital, IRCCS, 00146 Rome, Italy
    Department of Human Science, LUMSA University, 00193 Rome, Italy)

  • Silvia Di Vara

    (Child and Adolescent Neuropsychiatry Unit, Department of Neuroscience, Bambino Gesù Children’s Hospital, IRCCS, 00146 Rome, Italy)

  • Pietro De Rossi

    (Child and Adolescent Neuropsychiatry Unit, Department of Neuroscience, Bambino Gesù Children’s Hospital, IRCCS, 00146 Rome, Italy)

  • Italo Pretelli

    (Child and Adolescent Neuropsychiatry Unit, Department of Neuroscience, Bambino Gesù Children’s Hospital, IRCCS, 00146 Rome, Italy)

  • Stefano Vicari

    (Child and Adolescent Neuropsychiatry Unit, Department of Neuroscience, Bambino Gesù Children’s Hospital, IRCCS, 00146 Rome, Italy
    Department of Life Science and Public Health, Università Cattolica del Sacro Cuore, 00168 Rome, Italy
    Centro di Riabilitazione, Casa San Giuseppe, Opera Don Guanella, 00165 Rome, Italy)

  • Deny Menghini

    (Child and Adolescent Neuropsychiatry Unit, Department of Neuroscience, Bambino Gesù Children’s Hospital, IRCCS, 00146 Rome, Italy)

Abstract

Methylphenidate (MPH) is the treatment of first choice for developmental ADHD. To date, no reliable method to predict how patients will respond to MPH exists and conflicting results are reported on clinical characteristics of responders. The present study aims to give a more precise characterization of the patients who will respond best to MPH to help clinicians in defining the treatment plan. Age, neuropsychological functioning (i.e., attention and working memory), and behavioral/emotional symptoms of 48 drug-naïve children and adolescents with ADHD (42 boys and 6 girls, age-range 6–16 years, mean age 10.5 ± 2.5 years, mean IQ 101.3 ± 11.2) were studied to assess how these different characteristics affected a single-dose MPH response. Four hierarchical linear regression models were used to explore whether age, neuropsychological measures at baseline, and behavioral/emotional symptoms could predict attention and working memory measures after a single-dose MPH administration. We found that improvement in attention and working memory was predicted by age, neuropsychological measures at baseline, and severity of ADHD symptoms. No behavioral and emotional symptoms predicted single-dose MPH response with the exception of conduct symptoms.

Suggested Citation

  • Barbara D’Aiello & Silvia Di Vara & Pietro De Rossi & Italo Pretelli & Stefano Vicari & Deny Menghini, 2022. "Moderators and Other Predictors of Methylphenidate Response in Children and Adolescents with ADHD," IJERPH, MDPI, vol. 19(3), pages 1-10, January.
    • Handle: RePEc:gam:jijerp:v:19:y:2022:i:3:p:1640-:d:739698
    as

    Download full text from publisher

    File URL: https://www.mdpi.com/1660-4601/19/3/1640/pdf
    Download Restriction: no
    File URL: https://www.mdpi.com/1660-4601/19/3/1640/
    Download Restriction: no
    ---><---

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:gam:jijerp:v:19:y:2022:i:3:p:1640-:d:739698. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: MDPI Indexing Manager (email available below). General contact details of provider: https://www.mdpi.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.