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Effects of Periodontal Treatment in Patients with Periodontitis and Kidney Failure: A Pilot Study

Author

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  • Wen-Chen Chung

    (School of Dentistry, College of Oral Medicine, Taipei Medical University, Taipei 110, Taiwan
    Division of Periodontics, Department of Dentistry, Taipei Medical University Hospital, Taipei 110, Taiwan
    Division of Periodontics, Department of Dentistry, Shuang Ho Hospital, Taipei Medical University, New Taipei City 235, Taiwan
    These authors contributed equally to this work.)

  • Chih-Chin Kao

    (Division of Nephrology, Department of Internal Medicine, Taipei Medical University Hospital, Taipei 110, Taiwan
    Division of Nephrology, Department of Internal Medicine, School of Medicine, College of Medicine, Taipei Medical University, Taipei 110, Taiwan
    Taipei Medical University-Research Center of Urology and Kidney (TMU-RCUK), Taipei Medical University, Taipei 110, Taiwan
    These authors contributed equally to this work.)

  • Chiung-Fang Huang

    (Division of Family and Operative Dentistry, Department of Dentistry, Taipei Medical University Hospital, Taipei 110, Taiwan
    School of Dental Technology, College of Oral Medicine, Taipei Medical University, Taipei 110, Taiwan)

  • Chang-Yu Lee

    (Division of Periodontics, Department of Dentistry, Taipei Medical University Hospital, Taipei 110, Taiwan)

  • Hsein-Kun Lu

    (School of Dentistry, College of Oral Medicine, Taipei Medical University, Taipei 110, Taiwan
    Division of Periodontics, Department of Dentistry, Taipei Medical University Hospital, Taipei 110, Taiwan)

  • Mai-Szu Wu

    (Division of Nephrology, Department of Internal Medicine, School of Medicine, College of Medicine, Taipei Medical University, Taipei 110, Taiwan
    Taipei Medical University-Research Center of Urology and Kidney (TMU-RCUK), Taipei Medical University, Taipei 110, Taiwan
    Division of Nephrology, Department of Internal Medicine, Shuang Ho Hospital, Taipei Medical University, New Taipei City 235, Taiwan)

Abstract

Periodontitis and chronic kidney disease are both chronic inflammatory diseases and share some common risk factors. This 3-month pilot study aimed to clarify whether non-surgical periodontal therapy is beneficial in clinical, biochemical, and microbiological conditions in patients with periodontitis and kidney failure. Kidney failure patients with moderate to severe periodontitis were recruited from two hospitals. Treatment group received non-surgical periodontal therapy, and control group received oral hygiene instruction only. Outcome assessments were conducted 1 and 3 months after treatment. Non-parametric tests were used to analyze the patient-level data. Periodontal site-level assessments were analyzed by Student t -test and paired t -test. Statistical significance was set at p -value < 0.05. A total of 11 subjects completed the study. There was no significant difference between groups in all-cause mortality, cardiovascular events, infection events, systemic parameters, and serum biomarkers. Comparing to control group, clinical periodontal parameters, gingival crevicular fluid interleukin-1β (IL-1β) level and periodontal pathogens showed significant improvement in the treatment group. Non-surgical periodontal treatment did not change systemic outcomes in kidney failure patients, but changed the local micro-environment.

Suggested Citation

  • Wen-Chen Chung & Chih-Chin Kao & Chiung-Fang Huang & Chang-Yu Lee & Hsein-Kun Lu & Mai-Szu Wu, 2022. "Effects of Periodontal Treatment in Patients with Periodontitis and Kidney Failure: A Pilot Study," IJERPH, MDPI, vol. 19(3), pages 1-13, January.
    • Handle: RePEc:gam:jijerp:v:19:y:2022:i:3:p:1533-:d:737812
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    Cited by:

    1. Wen-Chen Chung & Chiung-Fang Huang & Sheng-Wei Feng, 2022. "Clinical Benefits of Minimally Invasive Non-Surgical Periodontal Therapy as an Alternative of Conventional Non-Surgical Periodontal Therapy—A Pilot Study," IJERPH, MDPI, vol. 19(12), pages 1-12, June.

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