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Partial Replacement of Dietary Fat with Krill Oil or Coconut Oil Alleviates Dyslipidemia by Partly Modulating Lipid Metabolism in Lipopolysaccharide-Injected Rats on a High-Fat Diet

Author

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  • Hee-Kyoung Son

    (Research Center for Industrialization of Natural Neutralization, Dankook University, Cheonan 31116, Korea
    These authors contributed equally to this work.)

  • Bok-Hee Kim

    (Department of Food and Nutrition, Chosun University, Gwangju 61452, Korea
    These authors contributed equally to this work.)

  • Jisu Lee

    (Research Center for Industrialization of Natural Neutralization, Dankook University, Cheonan 31116, Korea
    Department of Food Science and Nutrition, Dankook University, Cheonan 31116, Korea)

  • Seohyun Park

    (Research Center for Industrialization of Natural Neutralization, Dankook University, Cheonan 31116, Korea
    Department of Food Science and Nutrition, Dankook University, Cheonan 31116, Korea)

  • Chung-Bae Oh

    (Office of Technical Liaison, Industry Support Team, Gyeongnam Branch Institute, Korea Institute of Toxicology, Jinju 52834, Korea)

  • Sunyoon Jung

    (Research Center for Industrialization of Natural Neutralization, Dankook University, Cheonan 31116, Korea
    Department of Food Science and Nutrition, Dankook University, Cheonan 31116, Korea)

  • Jennifer K. Lee

    (Food Science and Human Nutrition Department, University of Florida, Gainesville, FL 32611, USA)

  • Jung-Heun Ha

    (Research Center for Industrialization of Natural Neutralization, Dankook University, Cheonan 31116, Korea
    Department of Food Science and Nutrition, Dankook University, Cheonan 31116, Korea)

Abstract

This study investigated the effects of partial replacement of dietary fat with krill oil (KO) or coconut oil (CO) on dyslipidemia and lipid metabolism in rats fed with a high-fat diet (HFD). Sprague Dawley rats were divided into three groups as follows: HFD, HFD + KO, and HFD + CO. The rats were fed each diet for 10 weeks and then intraperitoneally injected with phosphate-buffered saline (PBS) or lipopolysaccharide (LPS) (1 mg/kg). The KO- and CO-fed rats exhibited lower levels of serum lipids and aspartate aminotransferases than those of the HFD-fed rats. Rats fed with HFD + KO displayed significantly lower hepatic histological scores and hepatic triglyceride (TG) content than rats fed with HFD. The KO supplementation also downregulated the adipogenic gene expression in the liver. When treated with LPS, the HFD + KO and HFD + CO groups reduced the adipocyte size in the epididymal white adipose tissues (EAT) relative to the HFD group. These results suggest that KO and CO could improve lipid metabolism dysfunction.

Suggested Citation

  • Hee-Kyoung Son & Bok-Hee Kim & Jisu Lee & Seohyun Park & Chung-Bae Oh & Sunyoon Jung & Jennifer K. Lee & Jung-Heun Ha, 2022. "Partial Replacement of Dietary Fat with Krill Oil or Coconut Oil Alleviates Dyslipidemia by Partly Modulating Lipid Metabolism in Lipopolysaccharide-Injected Rats on a High-Fat Diet," IJERPH, MDPI, vol. 19(2), pages 1-30, January.
    • Handle: RePEc:gam:jijerp:v:19:y:2022:i:2:p:843-:d:723335
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    References listed on IDEAS

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    1. Hee-Kyoung Son & Huo Xiang & Seohyun Park & Jisu Lee & Jae-Joon Lee & Sunyoon Jung & Jung-Heun Ha, 2021. "Partial Replacement of Dietary Fat with Polyunsaturated Fatty Acids Attenuates the Lipopolysaccharide-Induced Hepatic Inflammation in Sprague-Dawley Rats Fed a High-Fat Diet," IJERPH, MDPI, vol. 18(20), pages 1-26, October.
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