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Impact of Exposome Factors on Epidermal Barrier Function in Patients with Obstructive Sleep Apnea Syndrome

Author

Listed:
  • Maria Romera-Vilchez

    (Dermatology Department, Faculty of Medicine, University of Granada, 18012 Granada, Spain
    These authors contributed equally to this work.)

  • Trinidad Montero-Vilchez

    (Dermatology Department, Hospital Universitario Virgen de las Nieves, 18012 Granada, Spain
    Instituto de Investigación Biosanitaria GRANADA, 18012 Granada, Spain
    These authors contributed equally to this work.)

  • Manuel Herrero-Fernandez

    (Dermatology Department, Faculty of Medicine, University of Granada, 18012 Granada, Spain)

  • Juan-Angel Rodriguez-Pozo

    (Dermatology Department, Hospital Universitario Virgen de las Nieves, 18012 Granada, Spain
    Instituto de Investigación Biosanitaria GRANADA, 18012 Granada, Spain)

  • Gonzalo Jimenez-Galvez

    (Pneumnology Department, Hospital Universitario Virgen de las Nieves, 18012 Granada, Spain)

  • Concepcion Morales-Garcia

    (Pneumnology Department, Hospital Universitario Virgen de las Nieves, 18012 Granada, Spain)

  • Agustin Buendia-Eisman

    (Dermatology Department, Faculty of Medicine, University of Granada, 18012 Granada, Spain)

  • Salvador Arias-Santiago

    (Dermatology Department, Faculty of Medicine, University of Granada, 18012 Granada, Spain
    Dermatology Department, Hospital Universitario Virgen de las Nieves, 18012 Granada, Spain
    Instituto de Investigación Biosanitaria GRANADA, 18012 Granada, Spain)

Abstract

Exposome factors, such as sleep deprivation and diet, could affect skin barrier function. The objectives of this study are to compare skin barrier function between patients with Obstructive Sleep Apnea Syndrome (OSAS) and healthy individuals, and to evaluate the effect of other exposome factors on skin. A cross-sectional study was conducted. Patients with OSAS and healthy volunteers matched by age and sex were included. OSAS severity was assessed by the Apnea-Hypopnea Index (AHI). Validated questionnaires were used to assess diet, anxiety, depression, and psychological stress. Skin barrier function parameters including temperature, erythema, melanin, pH, transepidermal water loss (TEWL), and stratum corneum hydration (SCH) were measured on the volar forearm. A total of 86 participants were included, 56 patients with OSAS and 30 healthy volunteers. TEWL was higher in OSAS patients than in healthy individuals (8.01 vs. 8.68 g·m −2 ·h −1 ). Regarding disease severity, severe patients had higher TEWL values (9.31 vs. 8.46 vs. 7.08 g·m −2 ·h −1 ) compared to moderate and mild patients. Patients with OSAS had significantly lower sleep quality (11.89 vs. 6.47 Pittsburgh Sleep Quality Index score; p < 0.001), poor adherence to the Mediterranean Diet (8.46 vs. 9.77; p = 0.005), and significantly higher anxiety and depression levels than healthy individuals. In conclusion, patients with OSAS may have skin barrier impairment, reflected in higher TEWL values. These patients also have higher levels of anxiety, depression, stress, and a lower adherence to a Mediterranean Diet, all exposome factors that might impact on skin barrier function.

Suggested Citation

  • Maria Romera-Vilchez & Trinidad Montero-Vilchez & Manuel Herrero-Fernandez & Juan-Angel Rodriguez-Pozo & Gonzalo Jimenez-Galvez & Concepcion Morales-Garcia & Agustin Buendia-Eisman & Salvador Arias-Sa, 2022. "Impact of Exposome Factors on Epidermal Barrier Function in Patients with Obstructive Sleep Apnea Syndrome," IJERPH, MDPI, vol. 19(2), pages 1-12, January.
    • Handle: RePEc:gam:jijerp:v:19:y:2022:i:2:p:659-:d:719601
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    References listed on IDEAS

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    1. Mahesh Nagappa & Pu Liao & Jean Wong & Dennis Auckley & Satya Krishna Ramachandran & Stavros Memtsoudis & Babak Mokhlesi & Frances Chung, 2015. "Validation of the STOP-Bang Questionnaire as a Screening Tool for Obstructive Sleep Apnea among Different Populations: A Systematic Review and Meta-Analysis," PLOS ONE, Public Library of Science, vol. 10(12), pages 1-21, December.
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