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Triptolide Attenuates Muscular Inflammation and Oxidative Stress in a Delayed-Onset Muscle Soreness Animal Model

Author

Listed:
  • Che-Chia Hsu

    (Department of Orthopaedics, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan 70428, Taiwan
    These authors contributed equally to the work.)

  • Chin-Chuan Tsai

    (Department of Traditional Chinese Medicine, E-Da Dachang Hospital, Kaohsiung 82445, Taiwan
    School of Chinese Medicine for Post Baccalaureate, I-Shou University, Kaohsiung 82445, Taiwan
    These authors contributed equally to the work.)

  • Po-Yen Ko

    (Department of Orthopaedics, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan 70428, Taiwan)

  • Ting-Hsien Kwan

    (Department of Orthopaedics, Ditmanson Medical Foundation Chia-Yi Christian Hospital, Chiayi 60002, Taiwan)

  • Ming-Yie Liu

    (Department of Environmental and Occupational Health, College of Medicine, National Cheng Kung University, Tainan 70428, Taiwan)

  • Po-Ting Wu

    (Department of Orthopaedics, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan 70428, Taiwan
    Medical Device Innovation Center, National Cheng Kung University, Tainan 70428, Taiwan
    Department of Orthopaedics, College of Medicine, National Cheng Kung University, Tainan 70428, Taiwan
    Department of Biomedical Engineering, National Cheng Kung University, Tainan 70428, Taiwan)

  • I-Ming Jou

    (Department of Orthopaedics, E-Da Hospital, Kaohsiung 82445, Taiwan
    School of Medicine, College of Medicine, I-Shou University, Kaohsiung 82445, Taiwan
    GEG Orthopedic Clinic, Tainan 74543, Taiwan)

Abstract

Delayed-onset muscle soreness (DOMS) is associated with exercise-induced muscle damage and inflammation, which is mainly caused by prolonged eccentric exercise in humans. Triptolide, an extract from the Chinese herb Tripterygium wilfordii Hook F, has been used for treating autoimmune and inflammatory diseases in clinical practice. However, whether triptolide attenuates acute muscle damage is still unclear. Here, we examined the effect of triptolide on carrageenan-induced DOMS in rats. Rats were injected with 3% of carrageenan into their muscles to induce acute left gastrocnemius muscular damage, and triptolide treatment attenuated carrageenan-induced acute muscular damage without affecting hepatic function. Triptolide can significantly decrease lipid hydroperoxide and nitric oxide (NO) levels, proinflammatory cytokine production, and the activation of nuclear factor (NF)-ĸB, as well as increase a reduced form of glutathione levels in carrageenan-treated rat muscles. At the enzyme levels, triptolide reduced the inducible nitric oxide synthase (iNOS) expression and muscular myeloperoxidase (MPO) activity in carrageenan-treated DOMS rats. In conclusion, we show that triptolide can attenuate muscular damage by inhibiting muscular oxidative stress and inflammation in a carrageenan-induced rat DOMS model.

Suggested Citation

  • Che-Chia Hsu & Chin-Chuan Tsai & Po-Yen Ko & Ting-Hsien Kwan & Ming-Yie Liu & Po-Ting Wu & I-Ming Jou, 2022. "Triptolide Attenuates Muscular Inflammation and Oxidative Stress in a Delayed-Onset Muscle Soreness Animal Model," IJERPH, MDPI, vol. 19(24), pages 1-11, December.
    • Handle: RePEc:gam:jijerp:v:19:y:2022:i:24:p:16685-:d:1000909
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