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Serum Phospholipids Are Potential Therapeutic Targets of Aqueous Extracts of Roselle ( Hibiscus sabdariffa ) against Obesity and Insulin Resistance

Author

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  • Carmen Alejandra Rangel-García

    (Centro de Investigación en Ciencia Aplicada y Tecnología Avanzada del Instituto Politécnico Nacional, Colinas del Cimatario, Queretaro 76090, Qro., Mexico)

  • Rosalía Reynoso-Camacho

    (Facultad de Química, Universidad Autónoma de Querétaro, C.U. Cerro de las Campanas, Queretaro 76010, Qro., Mexico)

  • Iza F. Pérez-Ramírez

    (Facultad de Química, Universidad Autónoma de Querétaro, C.U. Cerro de las Campanas, Queretaro 76010, Qro., Mexico)

  • Elizabeth Morales-Luna

    (Facultad de Química, Universidad Autónoma de Querétaro, C.U. Cerro de las Campanas, Queretaro 76010, Qro., Mexico)

  • Ericka A. de los Ríos

    (Instituto de Neurobiología, Universidad Nacional Autónoma de México, Campus Juriquilla, Juriquilla, Queretaro 76230, Qro., Mexico)

  • Luis M. Salgado

    (Centro de Investigación en Ciencia Aplicada y Tecnología Avanzada del Instituto Politécnico Nacional, Colinas del Cimatario, Queretaro 76090, Qro., Mexico)

Abstract

Roselle ( Hibiscus sabdariffa ) is rich in phenolic compounds with antiobesogenic and antidiabetic effects. In this study, the effects of aqueous extracts of two varieties of Hibiscus sabdariffa , Alma blanca (white-yellow color) and Cuarenteña (purple color), were evaluated for the prevention of obesity and insulin resistance in rats fed a high-fat and high-fructose diet (HFFD), identifying targeted molecules through global metabolomics. After sixteen weeks, both roselle aqueous extracts prevented body weight gain, and white roselle extract ameliorated insulin resistance and decreased serum free fatty acid levels. Moreover, white roselle extract decreased 18:0 and 20:4 lysophosphatidylethanolamines and purple roselle extract increased 16:0 and 20:4 lysophosphatidylinositol compared to HFFD-fed rats. These results demonstrate that roselle’s beneficial health effects are variety-dependent. Interestingly, the white roselle extract showed a greater beneficial effect, probably due to its high contents of organic and phenolic acids, though its consumption is not as popular as that of the red/purple varieties.

Suggested Citation

  • Carmen Alejandra Rangel-García & Rosalía Reynoso-Camacho & Iza F. Pérez-Ramírez & Elizabeth Morales-Luna & Ericka A. de los Ríos & Luis M. Salgado, 2022. "Serum Phospholipids Are Potential Therapeutic Targets of Aqueous Extracts of Roselle ( Hibiscus sabdariffa ) against Obesity and Insulin Resistance," IJERPH, MDPI, vol. 19(24), pages 1-16, December.
    • Handle: RePEc:gam:jijerp:v:19:y:2022:i:24:p:16538-:d:998263
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