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Salivary Diagnostic for Monitoring Strenuous Exercise—A Pilot Study in a Cohort of Male Ultramarathon Runners

Author

Listed:
  • Josephin Borchers

    (Department of Cariology, Endodontology and Periodontology, University of Leipzig, 04103 Leipzig, Germany
    These authors contributed equally to this work and should be considered joint first authors.)

  • Cordula Leonie Merle

    (Department of Prosthetic Dentistry, UKR University Hospital Regensburg, 93053 Regensburg, Germany
    Department of Cariology, Endodontology and Periodontology, University of Leipzig, 04103 Leipzig, Germany
    These authors contributed equally to this work and should be considered joint first authors.)

  • Deborah Diana Schöneborn

    (Department of Sports Medicine, Charité University Medicine, 10115 Berlin, Germany)

  • Lea Ronja Lyko

    (Department of Sports Medicine, Charité University Medicine, 10115 Berlin, Germany)

  • Thomas Thouet

    (Department of Sports Medicine, Charité University Medicine, 10115 Berlin, Germany)

  • Bernd Wolfarth

    (Department of Sports Medicine, Charité University Medicine, 10115 Berlin, Germany
    Department of Sports Medicine, Institute for Applied Scientific Training, 04109 Leipzig, Germany
    Institute of Sports Science, Humboldt University, 10115 Berlin, Germany)

  • Tanja Kottmann

    (CRO Dr. med Kottmann GmbH & Co. KG, 59077 Hamm, Germany)

  • Carmen Scheibenbogen

    (Institute for Medical Immunology, Charité University Medicine, 13353 Berlin, Germany)

  • Jeannot Zimmer

    (SYNLAB Medizinisches Versorgungszentrum Berlin GmbH, 10828 Berlin, Germany)

  • Sven Diederich

    (Medicover Berlin-Mitte, 10117 Berlin, Germany)

  • Katrin Bauer

    (Institute of Clinical Immunology, Medical Faculty, University of Leipzig, 04103 Leipzig, Germany)

  • Ulrich Sack

    (Institute of Clinical Immunology, Medical Faculty, University of Leipzig, 04103 Leipzig, Germany)

  • Gerhard Schmalz

    (Department of Cariology, Endodontology and Periodontology, University of Leipzig, 04103 Leipzig, Germany)

  • Dirk Ziebolz

    (Department of Cariology, Endodontology and Periodontology, University of Leipzig, 04103 Leipzig, Germany)

  • Jan Wüstenfeld

    (Department of Sports Medicine, Charité University Medicine, 10115 Berlin, Germany
    Department of Sports Medicine, Institute for Applied Scientific Training, 04109 Leipzig, Germany)

Abstract

Intense physical stress, such as that in ultramarathon running, affects the immune system. For monitoring in sports medicine, non-invasive methods, e.g., salivary analysis, are of interest. This pilot cohort study aimed to assess changes in salivary parameters in response to an ultramarathon. The results were compared to blood parameters. Male, healthy finishers ( n = 9, mean age: 48 ± 8.8 years, mean height: 1.8 ± 0.1 m, mean weight: 72.5 ± 7.2 kg, mean BMI: 23.5 ± 1.9 kg/cm²) of a 160 km ultramarathon were included. Saliva and blood samples were collected at three time points: T1 (baseline), T2 (shortly after the ultramarathon) and T3 (after recovery). In saliva, cortisol, testosterone, IL-1β, IL-6, IL-8, IL-10, TNF-α, albumin, IgA, α-amylase, aMMP-8, and neopterin were assessed via ELISA. In blood, cortisol, testosterone, IL-1β, IL-6, IL-8, IL-10, TNF-α, blood cell counts, procalcitonin, CRP, osmolality, albumin, and α-amylase were analyzed. The statistical evaluation comprised longitudinal testing and cross-sectional testing between saliva and blood using ratios of T2 and T3 to baseline values. Various parameters in saliva and blood changed in response to the ultramarathon. Comparing blood and saliva, the longitudinal changes of testosterone ( p = 0.02) and α-amylase ( p = 0.03) differed significantly. Despite the limitations of the study, it underlines that saliva is an interesting option for comprehensive monitoring in sports medicine and necessitates further studies.

Suggested Citation

  • Josephin Borchers & Cordula Leonie Merle & Deborah Diana Schöneborn & Lea Ronja Lyko & Thomas Thouet & Bernd Wolfarth & Tanja Kottmann & Carmen Scheibenbogen & Jeannot Zimmer & Sven Diederich & Katrin, 2022. "Salivary Diagnostic for Monitoring Strenuous Exercise—A Pilot Study in a Cohort of Male Ultramarathon Runners," IJERPH, MDPI, vol. 19(23), pages 1-14, December.
    • Handle: RePEc:gam:jijerp:v:19:y:2022:i:23:p:16110-:d:991061
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    References listed on IDEAS

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    1. Emanuela Faelli & Ambra Bisio & Roberto Codella & Vittoria Ferrando & Luisa Perasso & Marco Panascì & Daniele Saverino & Piero Ruggeri, 2020. "Acute and Chronic Catabolic Responses to CrossFit ® and Resistance Training in Young Males," IJERPH, MDPI, vol. 17(19), pages 1-15, September.
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