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Insight into the Molecular Signature of Skeletal Muscle Characterizing Lifelong Football Players

Author

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  • Stefania Orrù

    (Department of Movement Sciences and Wellness, University Parthenope, 80133 Naples, Italy
    CEINGE-Biotecnologie Avanzate Franco Salvatore, 80145 Naples, Italy
    These authors contributed equally to this work.)

  • Esther Imperlini

    (Department for Innovation in Biological, Agro-Food and Forest Systems, University of Tuscia, 01100 Viterbo, Italy
    These authors contributed equally to this work.)

  • Daniela Vitucci

    (Department of Movement Sciences and Wellness, University Parthenope, 80133 Naples, Italy
    CEINGE-Biotecnologie Avanzate Franco Salvatore, 80145 Naples, Italy)

  • Marianna Caterino

    (CEINGE-Biotecnologie Avanzate Franco Salvatore, 80145 Naples, Italy
    Department of Molecular Medicine and Medical Biotechnology, School of Medicine, University of Naples Federico II, 80131 Naples, Italy)

  • Annalisa Mandola

    (Department of Movement Sciences and Wellness, University Parthenope, 80133 Naples, Italy
    CEINGE-Biotecnologie Avanzate Franco Salvatore, 80145 Naples, Italy)

  • Morten Bredsgaard Randers

    (Department of Sports Science and Clinical Biomechanics, University of Southern Denmark, 5230 Odense, Denmark)

  • Jakob Friis Schmidt

    (Section for Anaesthesia for ENT, Head Neck & Maxillofacial Surgery and Ortopedi, Rigshospitalet, Copenhagen University Hospital, 2100 Copenhagen, Denmark)

  • Marie Hagman

    (Department of Sports Science and Clinical Biomechanics, University of Southern Denmark, 5230 Odense, Denmark)

  • Thomas Rostgaard Andersen

    (Department of Sports Science and Clinical Biomechanics, University of Southern Denmark, 5230 Odense, Denmark)

  • Peter Krustrup

    (Department of Sports Science and Clinical Biomechanics, University of Southern Denmark, 5230 Odense, Denmark
    Sport and Health Sciences, College of Life and Environmental Sciences, St. Luke’s Campus, University of Exeter, Exeter EX1 2LU, UK
    Danish Institute for Advanced Study (DIAS), University of Southern Denmark, 5230 Odense, Denmark)

  • Margherita Ruoppolo

    (CEINGE-Biotecnologie Avanzate Franco Salvatore, 80145 Naples, Italy
    Department of Molecular Medicine and Medical Biotechnology, School of Medicine, University of Naples Federico II, 80131 Naples, Italy)

  • Pasqualina Buono

    (Department of Movement Sciences and Wellness, University Parthenope, 80133 Naples, Italy
    CEINGE-Biotecnologie Avanzate Franco Salvatore, 80145 Naples, Italy)

  • Annamaria Mancini

    (Department of Movement Sciences and Wellness, University Parthenope, 80133 Naples, Italy
    CEINGE-Biotecnologie Avanzate Franco Salvatore, 80145 Naples, Italy)

Abstract

Background: Aging and sedentary behavior are independent risk factors for non-communicable diseases. An active lifestyle and structured physical activity are positively associated with a healthier quality of life in the elderly. Here, we explored the proteomic/metabolomic muscular signature induced by lifelong football training associated with successful aging. Methods: The study was performed on nine lifelong football players (67.3 ± 2.8 yrs) and nine aged-matched untrained subjects. We performed a proteomic/metabolomic approach on V. lateralis muscle biopsies; the obtained data were analyzed by means of different bioinformatic tools. Results: Our results indicated that lifelong football training is able to enhance the muscles’ oxidative capacity in the elderly by promoting fatty acids as preferential energetic substrates and hence determining a healthier body composition and metabolic profile; furthermore, we showed that the total polyamine content is higher in lifelong football players’ muscle, enforcing the involvement of polyamines in muscle growth and hypertrophy. Conclusions: Lifelong football training, as a structured physical activity, significantly influences the expression of the proteins and metabolites involved in oxidative metabolism and muscle hypertrophy associated with successful aging.

Suggested Citation

  • Stefania Orrù & Esther Imperlini & Daniela Vitucci & Marianna Caterino & Annalisa Mandola & Morten Bredsgaard Randers & Jakob Friis Schmidt & Marie Hagman & Thomas Rostgaard Andersen & Peter Krustrup , 2022. "Insight into the Molecular Signature of Skeletal Muscle Characterizing Lifelong Football Players," IJERPH, MDPI, vol. 19(23), pages 1-19, November.
    • Handle: RePEc:gam:jijerp:v:19:y:2022:i:23:p:15835-:d:986501
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    References listed on IDEAS

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    1. Esther Imperlini & Annamaria Mancini & Stefania Orrù & Daniela Vitucci & Valeria Di Onofrio & Francesca Gallè & Giuliana Valerio & Giuliana Salvatore & Giorgio Liguori & Pasqualina Buono & Andreina Al, 2020. "Long-Term Recreational Football Training and Health in Aging," IJERPH, MDPI, vol. 17(6), pages 1-15, March.
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    1. Natália Cristina de Oliveira & Pedro Balikian Júnior & Arnaldo Tenório da Cunha Júnior & Edson de Souza Bento & Josealdo Tonholo & Thiago Aquino & Filipe Antonio de Barros Sousa & Gustavo Gomes de Ara, 2023. "Environmental Planning and Non-Communicable Diseases: A Systematic Review on the Role of the Metabolomic Profile," IJERPH, MDPI, vol. 20(14), pages 1-15, July.

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