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Association between IL-1 Gene Polymorphisms and Stage III Grade B Periodontitis in Polish Population

Author

Listed:
  • Aniela Brodzikowska

    (Department of Conservative Dentistry, Medical University of Warsaw, 02-097 Warsaw, Poland)

  • Bartłomiej Górski

    (Department of Periodontology and Oral Mucosa Diseases, Medical University of Warsaw, 02-097 Warsaw, Poland)

  • Agnieszka Bogusławska-Kapała

    (Department of Comprehensive Dental Care, Medical University of Warsaw, 02-097 Warsaw, Poland)

Abstract

Periodontitis is a chronic multifactorial inflammatory disease originating from microbial, environmental and genetic factors. The present study aimed to find an association of genetic polymorphisms at IL-1A −889 and IL-1B +3953 loci in Polish patients with stage III grade B periodontitis and periodontally healthy subjects. Fifty patients with stage III grade B periodontitis (tests) and thirty-five periodontally healthy controls were included in the study. To determine IL-1A and IL-1B gene polymorphisms, buccal swab-derived DNA obtained by means of the GenoType PST test was used. There were no statistically significant differences regarding the prevalence of IL-1A −889 or IL-1B +3953 alleles between groups. The frequencies of different IL-1A −889 genotypes did not differ significantly between groups. The IL-1B +3953 C/T genotype was significantly more predominant in periodontitis patients than in controls, whereas C/C genotype prevalence was significantly lower in the test group. Complex genotypes consisting of at least one IL-1A −889 and IL-1B +3953 T allele occurred significantly more frequently in subjects with periodontitis. Stage III grade B periodontitis may be associated with the IL-1B +3953 T allele and composite IL-1 polymorphism. Reduced susceptibility to periodontal disease was present in IL-1A −889 and IL-1B +3953 C/C homozygotic patients.

Suggested Citation

  • Aniela Brodzikowska & Bartłomiej Górski & Agnieszka Bogusławska-Kapała, 2022. "Association between IL-1 Gene Polymorphisms and Stage III Grade B Periodontitis in Polish Population," IJERPH, MDPI, vol. 19(22), pages 1-11, November.
    • Handle: RePEc:gam:jijerp:v:19:y:2022:i:22:p:14687-:d:967116
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