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The Prevalence of Anticitrullinated Protein Antibodies in Older Poles—Results from a Population-Based PolSenior Study

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  • Anna Chudek

    (Health Promotion and Obesity Management Unit, Department of Pathophysiology, Faculty of Medical Sciences in Katowice, Medical University of Silesia in Katowice, 40-752 Katowice, Poland)

  • Przemysław Kotyla

    (Department of Internal Medicine, Rheumatology and Clinical Immunology, Faculty of Medical Sciences in Katowice, Medical University of Silesia in Katowice, 40-635 Katowice, Poland)

  • Małgorzata Mossakowska

    (Study on Ageing and Longevity, International Institute of Molecular and Cell Biology, 02-109 Warsaw, Poland)

  • Tomasz Grodzicki

    (Department of Internal Medicine and Gerontology, Jagiellonian University Medical College, 31-531 Krakow, Poland)

  • Tomasz Zdrojewski

    (Division of Preventive Medicine and Education, Medical University of Gdansk, 80-211 Gdansk, Poland)

  • Magdalena Olszanecka-Glinianowicz

    (Health Promotion and Obesity Management Unit, Department of Pathophysiology, Faculty of Medical Sciences in Katowice, Medical University of Silesia in Katowice, 40-752 Katowice, Poland)

  • Jerzy Chudek

    (Department of Internal Medicine and Oncological Chemotherapy, Medical University of Silesia, 40-029 Katowice, Poland)

  • Aleksander J. Owczarek

    (Health Promotion and Obesity Management Unit, Department of Pathophysiology, Faculty of Medical Sciences in Katowice, Medical University of Silesia in Katowice, 40-752 Katowice, Poland)

Abstract

Little is known about the occurrence of antibodies in older subjects. We analyzed the prevalence of anticitrullinated protein antibodies (anti-CCP) in a representative cohort of Polish older adults, participants of PolSenior substudy. Randomly selected 1537 serum samples of community-dwelling participants aged 65 and over. Questionnaires were completed by qualified interviewers and laboratory assessments served as a database for this analysis. The frequency of anti-CCP seropositivity (N = 50) was estimated at 3.25% (95% CI: 2.45–4.30%), being higher among women—4.05% (2.83–5.73%) than men—2.41% (1.48–3.86%). The frequency of anti-CCP seropositivity was decreasing with age from 4.29% in aged 65–74 years and 4.07% in 70–84 years to 1.50% in aged 85 years or above ( p < 0.05). Hypoalbuminemia, inflammatory status (C-reactive protein >10 mg/dL or interleukin-6 ≥10 pg/mL), and female gender were associated with increased, while age ≥85 years with decreased risk of seropositivity. Multivariable logistic regression revealed that hypoalbuminemia, inflammatory status, and age ≥85 years were independently associated factors of anti-CCP seropositivity. The decreased frequency of anti-CCP seropositivity in the oldest old suggests shorter survival of the seropositive individuals who developed rheumatoid arthritis. It seems that low symptomatic RA remains frequently undiagnosed in older subjects.

Suggested Citation

  • Anna Chudek & Przemysław Kotyla & Małgorzata Mossakowska & Tomasz Grodzicki & Tomasz Zdrojewski & Magdalena Olszanecka-Glinianowicz & Jerzy Chudek & Aleksander J. Owczarek, 2022. "The Prevalence of Anticitrullinated Protein Antibodies in Older Poles—Results from a Population-Based PolSenior Study," IJERPH, MDPI, vol. 19(21), pages 1-12, October.
    • Handle: RePEc:gam:jijerp:v:19:y:2022:i:21:p:14216-:d:958498
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    References listed on IDEAS

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    1. Mateusz Winder & Aleksander J. Owczarek & Małgorzata Mossakowska & Katarzyna Broczek & Tomasz Grodzicki & Łukasz Wierucki & Jerzy Chudek, 2021. "Prevalence of Hyperuricemia and the Use of Allopurinol in Older Poles—Results from a Population-Based PolSenior Study," IJERPH, MDPI, vol. 18(2), pages 1-14, January.
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