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Cocktail Effect of Endocrine Disrupting Chemicals: Application to Chlorpyrifos in Lavender Essential Oils

Author

Listed:
  • Sophie Fouyet

    (Université Paris cité, CNRS CiTCoM, 75006 Paris, France
    Laboratoires Léa Nature, 17180 Périgny, France)

  • Elodie Olivier

    (Université Paris cité, CNRS CiTCoM, 75006 Paris, France)

  • Pascale Leproux

    (Université Paris cité, CNRS CiTCoM, 75006 Paris, France)

  • Sabrina Boutefnouchet

    (Université Paris cité, CNRS CiTCoM, 75006 Paris, France)

  • Mélody Dutot

    (Université Paris cité, CNRS CiTCoM, 75006 Paris, France
    Yslab, Recherche & Développement, 29000 Quimper, France)

  • Patrice Rat

    (Université Paris cité, CNRS CiTCoM, 75006 Paris, France)

Abstract

Chlorpyrifos is a pesticide that is toxic to human health and has been banned for the past decade. Due to its persistent and bioaccumulative properties, chlorpyrifos is still present in soil. Pregnant women can be exposed to chlorpyrifos through drinking water and herbal products, such as essential oils (EOs), resulting in adverse effects to the mother and fetus. Our objective was to evaluate and compare the potential endocrine disrupting effects of chlorpyrifos “free” or in contaminated lavender EO. We studied the release of four hormones and the activation of the P2X7 cell death receptor in human placental JEG-Tox cells as key biomarkers of endocrine toxicity for pregnant women (hPlacentox assay). We observed that “free” chlorpyrifos disrupted placental hormones and activated the P2X7 receptor, whereas chlorpyrifos in lavender EO disrupted only the placental hormones. We confirm that chlorpyrifos can be classified as an endocrine disrupting chemical (EDC) for pregnant women and point out that its endocrine disrupting effect may not be apparent when present in lavender EOs. Our results reveal the existence of specific reverse cocktail effects that may have protective properties against EDCs.

Suggested Citation

  • Sophie Fouyet & Elodie Olivier & Pascale Leproux & Sabrina Boutefnouchet & Mélody Dutot & Patrice Rat, 2022. "Cocktail Effect of Endocrine Disrupting Chemicals: Application to Chlorpyrifos in Lavender Essential Oils," IJERPH, MDPI, vol. 19(19), pages 1-11, October.
    • Handle: RePEc:gam:jijerp:v:19:y:2022:i:19:p:12984-:d:938364
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