IDEAS home Printed from https://ideas.repec.org/a/gam/jijerp/v19y2022i19p12913-d936817.html
   My bibliography  Save this article

African American Females Are Less Metabolically Flexible Compared with Caucasian American Females following a Single High-Fat Meal: A Pilot Study

Author

Listed:
  • Alyssa A. Olenick

    (Division of Endocrinology, Metabolism & Diabetes, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA)

  • Regis C. Pearson

    (Division of Endocrinology, Metabolism & Diabetes, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA)

  • Nuha Shaker

    (Department of Pathology and Lab Medicine, University of Kentucky, Lexington, KY 40536, USA)

  • Maire M. Blankenship

    (School of Nursing and Allied Health, Western Kentucky University, Bowling Green, KY 42101, USA)

  • Rachel A. Tinius

    (School of Kinesiology, Recreation, and Sport, Western Kentucky University, Bowling Green, KY 42101, USA)

  • Lee J. Winchester

    (Department of Kinesiology, College of Education, The University of Alabama, Tuscaloosa, AL 35487, USA)

  • Evie Oregon

    (School of Kinesiology, Recreation, and Sport, Western Kentucky University, Bowling Green, KY 42101, USA)

  • Jill M. Maples

    (Department of Obstetrics and Gynecology, University of Tennessee Graduate School of Medicine, Knoxville, TN 37920, USA)

Abstract

The relationship between metabolic flexibility (MF) and components of metabolic disease has not been well-studied among African American (AA) females and may play a role in the higher incidence of chronic disease among them compared with Caucasian American (CA) females. This pilot study aimed to compare the metabolic response of AA and CA females after a high-fat meal. Eleven AA (25.6 (5.6) y, 27.2 (6.0) kg/m 2 , 27.5 (9.7) % body fat) and twelve CA (26.5 (1.5) y, 25.7 (5.3) kg/m 2 , 25.0 (7.4) % body fat) women free of cardiovascular and metabolic disease and underwent a high-fat meal challenge (55.9% fat). Lipid oxidation, insulin, glucose, and interleukin (IL)-8 were measured fasted, 2 and 4 h postprandial. AA females had a significantly lower increase in lipid oxidation from baseline to 2 h postprandial ( p = 0.022), and trended lower at 4 h postprandial ( p = 0.081) compared with CA females, indicating worse MF. No group differences in insulin, glucose or HOMA-IR were detected. IL-8 was significantly higher in AA females compared with CA females at 2 and 4 h postprandial ( p = 0.016 and p = 0.015, respectively). These findings provide evidence of metabolic and inflammatory disparities among AA females compared with CA females that could serve as a predictor of chronic disease in individuals with a disproportionately higher risk of development.

Suggested Citation

  • Alyssa A. Olenick & Regis C. Pearson & Nuha Shaker & Maire M. Blankenship & Rachel A. Tinius & Lee J. Winchester & Evie Oregon & Jill M. Maples, 2022. "African American Females Are Less Metabolically Flexible Compared with Caucasian American Females following a Single High-Fat Meal: A Pilot Study," IJERPH, MDPI, vol. 19(19), pages 1-11, October.
    • Handle: RePEc:gam:jijerp:v:19:y:2022:i:19:p:12913-:d:936817
    as

    Download full text from publisher

    File URL: https://www.mdpi.com/1660-4601/19/19/12913/pdf
    Download Restriction: no
    File URL: https://www.mdpi.com/1660-4601/19/19/12913/
    Download Restriction: no
    ---><---

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:gam:jijerp:v:19:y:2022:i:19:p:12913-:d:936817. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: MDPI Indexing Manager (email available below). General contact details of provider: https://www.mdpi.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.