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Crocus Sativus for Insomnia: A Systematic Review and Meta-Analysis

Author

Listed:
  • Mohd Puad Munirah

    (Department of Family Medicine, School of Medical Sciences, Universiti Sains Malaysia, Kubang Kerian, Kota Bharu 16150, Malaysia)

  • Mohd Noor Norhayati

    (Department of Family Medicine, School of Medical Sciences, Universiti Sains Malaysia, Kubang Kerian, Kota Bharu 16150, Malaysia)

  • Mohamad Noraini

    (School of Dental Sciences, Health Campus, Universiti Sains Malaysia, Kubang Kerian, Kota Bharu 16150, Malaysia)

Abstract

Insomnia is a common complaint affecting human performance in daily life activities. This study aimed to analyze the effects of Crocus sativus on insomnia. Methods: PRISMA guidelines were used according to the PICOS model. A systematic search of PubMed/Medline and the Cochrane Library was undertaken for literature until December 2021. A random effects model was used with I 2 statistic to assess heterogeneity and a GRADE assessment was used to assess the quality of the outcomes. Eight articles were included, involving 431 participants. Crocus sativus reduced insomnia severity (SMD: 0.53; 95%CI: −0.05 to 1.11; I 2 statistic = 59%; p = 0.08) and increased sleep quality (SMD 0.89, 95% CI 0.10 to 1.68; I 2 statistic = 90%; p = 0.03; 6 studies, 308 participants, very low-quality evidence) and duration (SMD: 0.57; 95%CI: 0.21 to 0.93; I 2 statistic = 40%; p = 0.002; 5 studies; 220 participants, moderate-quality evidence) compared with the placebos. Although there is limited evidence of a very low- to moderate-quality, Crocus sativus may benefit people with insomnia. This non-pharmacological intervention may reduce the chance of adults with insomnia taking sedative–hypnotic medication, thus reducing dependency and withdrawal symptoms.

Suggested Citation

  • Mohd Puad Munirah & Mohd Noor Norhayati & Mohamad Noraini, 2022. "Crocus Sativus for Insomnia: A Systematic Review and Meta-Analysis," IJERPH, MDPI, vol. 19(18), pages 1-16, September.
    • Handle: RePEc:gam:jijerp:v:19:y:2022:i:18:p:11658-:d:916210
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    References listed on IDEAS

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    1. Amira Mohammed Ali & Abdulmajeed A. Alkhamees & Hiroaki Hori & Yoshiharu Kim & Hiroshi Kunugi, 2021. "The Depression Anxiety Stress Scale 21: Development and Validation of the Depression Anxiety Stress Scale 8-Item in Psychiatric Patients and the General Public for Easier Mental Health Measurement in ," IJERPH, MDPI, vol. 18(19), pages 1-20, September.
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