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Impact of Impulsivity, Hyperactivity, and Inattention on Discontinuation Rate among Opioid-Dependent Patients Treated with Extended-Release Naltrexone

Author

Listed:
  • Ann Tarja Karlsson

    (Addiction Unit, Sørlandet Hospital HF, 4604 Kristiansand, Norway)

  • John-Kåre Vederhus

    (Addiction Unit, Sørlandet Hospital HF, 4604 Kristiansand, Norway)

  • Thomas Clausen

    (Addiction Unit, Sørlandet Hospital HF, 4604 Kristiansand, Norway
    Norwegian Centre for Addiction Research, University of Oslo, 0315 Oslo, Norway)

  • Bente Weimand

    (Center for Mental Health and Substance Abuse, University of South-Eastern Norway, 3040 Drammen, Norway
    Department of R&D in Psychiatric Health Care, Akershus University Hospital, 1478 Oslo, Norway)

  • Kristin Klemmetsby Solli

    (Norwegian Centre for Addiction Research, University of Oslo, 0315 Oslo, Norway
    Department of R&D in Psychiatric Health Care, Akershus University Hospital, 1478 Oslo, Norway
    Vestfold Hospital Trust, 3103 Tønsberg, Norway)

  • Lars Tanum

    (Department of R&D in Psychiatric Health Care, Akershus University Hospital, 1478 Oslo, Norway
    Faculty for Health Science, Oslo Metropolitan University, 0130 Oslo, Norway)

Abstract

Previous studies have indicated elevated levels of impulsivity, hyperactivity, and inattention (IHI) among opioid-dependent patients seeking outpatient treatment with extended-release naltrexone (XR-NTX). This led us to hypothesize that IHI may be associated with a higher discontinuation rate for XR-NTX treatment. In a group of 162 patients with opioid dependence, discontinuation prior to the full 24 weeks of the study period (six injections and attending the study visit at 24 weeks) occurred in 49% of the patients, primarily in the early stage of treatment. IHI above the clinical cut-off on the adult ADHD self-report scale (ASRS) was not associated with a risk of premature discontinuation. This finding was not altered when controlling for socio-demographics, substance, use and mental health severity. Conclusively, high levels of IHI per se is not contradictive for XR-NTX treatment in regard to concern for premature discontinuation.

Suggested Citation

  • Ann Tarja Karlsson & John-Kåre Vederhus & Thomas Clausen & Bente Weimand & Kristin Klemmetsby Solli & Lars Tanum, 2022. "Impact of Impulsivity, Hyperactivity, and Inattention on Discontinuation Rate among Opioid-Dependent Patients Treated with Extended-Release Naltrexone," IJERPH, MDPI, vol. 19(18), pages 1-8, September.
    • Handle: RePEc:gam:jijerp:v:19:y:2022:i:18:p:11435-:d:912324
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