IDEAS home Printed from https://ideas.repec.org/a/gam/jijerp/v19y2022i18p11318-d910454.html
   My bibliography  Save this article

Human Evidence of Perfluorooctanoic Acid (PFOA) Exposure on Hepatic Disease: A Systematic Review and Meta-Analysis

Author

Listed:
  • Jihee Choi

    (Department of Food and Nutrition, College of Bionanotechnology, Gachon University, Seongnam-si 13120, Gyeonggi-do, Korea
    Institute for Aging and Clinical Nutrition Research, Gachon University, Seongnam-si 13120, Gyeonggi-do, Korea)

  • Jong-Yeon Kim

    (Institute for Aging and Clinical Nutrition Research, Gachon University, Seongnam-si 13120, Gyeonggi-do, Korea
    Department of Food Science and Biotechnology, Gachon University, Seongnam-si 13120, Gyeonggi-do, Korea)

  • Hae-Jeung Lee

    (Department of Food and Nutrition, College of Bionanotechnology, Gachon University, Seongnam-si 13120, Gyeonggi-do, Korea
    Institute for Aging and Clinical Nutrition Research, Gachon University, Seongnam-si 13120, Gyeonggi-do, Korea)

Abstract

Background: Perfluorooctanoic acid (PFOA) is widely used throughout different industries, including the food industry, because it is resistant to heat and prevents water or oil from easily permeating into or contaminating materials coated by PFOA. Although many studies have reported an association between PFOA exposure and the risk of developing hepatic diseases, it is still in debate because they have shown conflicting results. Therefore, this study conducted a systematic review and meta-analysis on the relationship between PFOA exposure and hepatic diseases. Methods: This study searched studies related to hepatic diseases due to PFOA exposure until 31 December 2021, using PubMed, EMBASE, and Web of Science. This study performed a systematic review and meta-analysis through research question development, literature screening, data extraction, and risk of bias evaluation. This study found 8280 studies after excluding duplicate literature and selected 5 studies in the final stage. Among them, two studies were included in the meta-analysis. Results: The results of the meta-analysis showed that the ALT of people exposed to PFOA was 117% higher than the ALT of those not exposed to PFOA, and it was significantly different (OR = 1.167; 95% CI, 1.086–1.254). Conclusion: However, since the number of studies included in the analysis was not large enough to conclude that PFOA exposure was associated with the development of hepatic diseases, more observational studies are needed to confirm its long-term effects.

Suggested Citation

  • Jihee Choi & Jong-Yeon Kim & Hae-Jeung Lee, 2022. "Human Evidence of Perfluorooctanoic Acid (PFOA) Exposure on Hepatic Disease: A Systematic Review and Meta-Analysis," IJERPH, MDPI, vol. 19(18), pages 1-10, September.
  • Handle: RePEc:gam:jijerp:v:19:y:2022:i:18:p:11318-:d:910454
    as

    Download full text from publisher

    File URL: https://www.mdpi.com/1660-4601/19/18/11318/pdf
    Download Restriction: no

    File URL: https://www.mdpi.com/1660-4601/19/18/11318/
    Download Restriction: no
    ---><---

    References listed on IDEAS

    as
    1. Siti Suhana Abdullah Soheimi & Amirah Abdul Rahman & Normala Abd Latip & Effendi Ibrahim & Siti Hamimah Sheikh Abdul Kadir, 2021. "Understanding the Impact of Perfluorinated Compounds on Cardiovascular Diseases and Their Risk Factors: A Meta-Analysis Study," IJERPH, MDPI, vol. 18(16), pages 1-22, August.
    2. Pingping Liu & Fang Yang & Yongbo Wang & Zhanpeng Yuan, 2018. "Perfluorooctanoic Acid (PFOA) Exposure in Early Life Increases Risk of Childhood Adiposity: A Meta-Analysis of Prospective Cohort Studies," IJERPH, MDPI, vol. 15(10), pages 1-14, September.
    Full references (including those not matched with items on IDEAS)

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Zhiqiang Zong & Mengjie Zhao & Mengyue Zhang & Kexin Xu & Yunquan Zhang & Xiujun Zhang & Chengyang Hu, 2022. "Association between PM 1 Exposure and Lung Function in Children and Adolescents: A Systematic Review and Meta-Analysis," IJERPH, MDPI, vol. 19(23), pages 1-17, November.

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.

      Corrections

      All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:gam:jijerp:v:19:y:2022:i:18:p:11318-:d:910454. See general information about how to correct material in RePEc.

      If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

      If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

      If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

      For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: MDPI Indexing Manager (email available below). General contact details of provider: https://www.mdpi.com .

      Please note that corrections may take a couple of weeks to filter through the various RePEc services.

      IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.