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Evaluation of the Influence of Biological Factors during the Course of Treatment in Patients with Ovarian Cancer

Author

Listed:
  • Daria Schneider-Matyka

    (Department of Nursing, Pomeranian Medical University in Szczecin, 71-210 Szczecin, Poland)

  • Edyta Skwirczyńska

    (Department of History of Medicine and Medical Ethics, Pomeranian Medical University in Szczecin, 70-205 Szczecin, Poland)

  • Maria Gaur

    (Department of Gynecological Surgery and Gynecological Oncology of Adults and Adolescents, Pomeranian Medical University in Szczecin, 70-111 Szczecin, Poland)

  • Beata Hukowska-Szematowicz

    (Institute of Biology, University of Szczecin, 71-412 Szczecin, Poland
    Molecular Biology and Biotechnology Center, University of Szczecin, 71-412 Szczecin, Poland)

  • Sebastian Kwiatkowski

    (Department of Obstetrics and Gynecology, Pomeranian Medical University in Szczecin, 70-111 Szczecin, Poland)

  • Marzena Mikla

    (Department of Nursing, University of Murcia, Campus de Ciencias, El Palmar, 30120 Murcia, Spain
    Group ENFERAVANZA, Murcian Institute of Biosanitary Research (IMIB), 30120 Murcia, Spain)

  • Elżbieta Grochans

    (Department of Nursing, Pomeranian Medical University in Szczecin, 71-210 Szczecin, Poland)

  • Aneta Cymbaluk-Płoska

    (Department of Gynecological Surgery and Gynecological Oncology of Adults and Adolescents, Pomeranian Medical University in Szczecin, 70-111 Szczecin, Poland)

Abstract

The aim of this study was to evaluate the influence of β-endorphins and serotonin on the course of treatment, disease-free time, and overall survival of patients with ovarian cancer. This study may contribute to the identification of modifiable factors that may influence the treatment of ovarian cancer. The research was carried out in a group of 162 patients of which 139 respondents were included in the research; ovarian cancer was diagnosed in 78 of these patients. The study consisted of three stages. In the first stage of diagnostics, a survey among the patients was carried out. In the second stage—5 mL of blood was collected from each patient ( n = 139) in the preoperative period to determine the concentration of β-endorphin and serotonin. In the third stage—blood samples were collected from those patients who had completed chemotherapy treatment or had surgery. Concentrations of β-endorphin and serotonin were measured by the Luminex method, using the commercial Luminex Human Discovery Assay kit. The average age of the patients was 62.99 years. The level of β-endorphin significantly differs among patients diagnosed with ovarian cancer and among patients in the control group (202.86; SD—15.78 vs. 302.00; SD—24.49). A lower level of β-endorphins was found in the patients with a recurrence of the neoplastic process compared to those without recurrence (178.84; SD—12.98 vs. 205.66; SD—13.37). On the other hand, the level of serotonin before chemotherapy was higher in the group of people with disease recurrence compared to those without recurrence (141.53; SD—15.33 vs. 134.99; SD—10.08). Statistically significantly positive correlations were found between the level of β-endorphin and both disease-free time (β-endorphin levels before chemotherapy: rho Spearman 0.379, p < 0.027; β-endorphin levels after chemotherapy: rho Spearman 0.734 p < 0.001) and survival time (β-endorphin levels before chemotherapy: rho Spearman 0.267, p < 0.018; β-endorphin levels after chemotherapy: rho Spearman 0.654 p < 0.001). 1. The levels of serotonin and β-endorphin levels are significantly related to ovarian cancer and change during treatment. 2. High mean preoperative concentrations of β-endorphins were significantly related to overall survival and disease-free time.

Suggested Citation

  • Daria Schneider-Matyka & Edyta Skwirczyńska & Maria Gaur & Beata Hukowska-Szematowicz & Sebastian Kwiatkowski & Marzena Mikla & Elżbieta Grochans & Aneta Cymbaluk-Płoska, 2022. "Evaluation of the Influence of Biological Factors during the Course of Treatment in Patients with Ovarian Cancer," IJERPH, MDPI, vol. 19(17), pages 1-14, August.
    • Handle: RePEc:gam:jijerp:v:19:y:2022:i:17:p:10516-:d:895882
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    References listed on IDEAS

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    1. Nani Morgan & Michael R Irwin & Mei Chung & Chenchen Wang, 2014. "The Effects of Mind-Body Therapies on the Immune System: Meta-Analysis," PLOS ONE, Public Library of Science, vol. 9(7), pages 1-14, July.
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