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The Clinical Significance of Urinary Retinol-Binding Protein 4: A Review

Author

Listed:
  • Krzysztof Ratajczyk

    (Department of Urology, Regional Specialist Hospital in Wroclaw, Kamienskiego 73a, 51-124 Wroclaw, Poland)

  • Andrzej Konieczny

    (Department of Nephrology and Transplantation Medicine, Wroclaw Medical University, Borowska 213, 50-556 Wroclaw, Poland)

  • Adrian Czekaj

    (Department of Urology, Regional Specialist Hospital in Wroclaw, Kamienskiego 73a, 51-124 Wroclaw, Poland)

  • Paweł Piotrów

    (Department of Urology, Regional Specialist Hospital in Wroclaw, Kamienskiego 73a, 51-124 Wroclaw, Poland)

  • Marek Fiutowski

    (Department of Urology, Regional Specialist Hospital in Wroclaw, Kamienskiego 73a, 51-124 Wroclaw, Poland)

  • Kornelia Krakowska

    (Department of Nephrology and Transplantation Medicine, Wroclaw Medical University, Borowska 213, 50-556 Wroclaw, Poland)

  • Paweł Kowal

    (Department of Urology, Regional Specialist Hospital in Wroclaw, Kamienskiego 73a, 51-124 Wroclaw, Poland)

  • Wojciech Witkiewicz

    (Research and Development Center, Regional Specialist Hospital in Wroclaw, Kamienskiego 73a, 51-124 Wroclaw, Poland)

  • Karolina Marek-Bukowiec

    (Research and Development Center, Regional Specialist Hospital in Wroclaw, Kamienskiego 73a, 51-124 Wroclaw, Poland)

Abstract

Effective biomarkers for early diagnosis, prognostication, and monitoring in renal diseases (in general) comprise an unmet need. Urinary retinol-binding protein 4, which is the most sensitive indicator of renal tubular damage, holds great promise as a universal biomarker for renal pathologies, in which tubular injury is the driving force. Here, we summarize the most important existing data on the associations between urinary retinol-binding protein 4 and renal diseases and highlight the untapped potential of retinol-binding protein 4 in clinical use.

Suggested Citation

  • Krzysztof Ratajczyk & Andrzej Konieczny & Adrian Czekaj & Paweł Piotrów & Marek Fiutowski & Kornelia Krakowska & Paweł Kowal & Wojciech Witkiewicz & Karolina Marek-Bukowiec, 2022. "The Clinical Significance of Urinary Retinol-Binding Protein 4: A Review," IJERPH, MDPI, vol. 19(16), pages 1-13, August.
    • Handle: RePEc:gam:jijerp:v:19:y:2022:i:16:p:9878-:d:885262
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    Keywords

    urinary RBP4; renal diseases; biomarker;
    All these keywords.

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