IDEAS home Printed from https://ideas.repec.org/a/gam/jijerp/v19y2022i15p9282-d875117.html
   My bibliography  Save this article

Bone Infarcts and Tumorigenesis—Is There a Connection? A Mini-Mapping Review

Author

Listed:
  • Wojciech Konarski

    (Department of Orthopaedic Surgery, Ciechanów Hospital, 06-400 Ciechanów, Poland)

  • Tomasz Poboży

    (Department of Orthopaedic Surgery, Ciechanów Hospital, 06-400 Ciechanów, Poland)

  • Martyna Hordowicz

    (General Psychiatry Unit III, Dr Barbara Borzym’s Independent Public Regional Psychiatric Health Care Center, 26-600 Radom, Poland)

  • Andrzej Śliwczyński

    (Department of Social and Preventive Medicine, Social Medicine Institute, Medical University of Lodz, 90-647 Lodz, Poland)

  • Ireneusz Kotela

    (Department of Orthopedic Surgery and Traumatology, Central Research Hospital of Ministry of Interior, Wołoska 137, 02-507 Warsaw, Poland)

  • Jan Krakowiak

    (Department of Social and Preventive Medicine, Social Medicine Institute, Medical University of Lodz, 90-647 Lodz, Poland)

  • Andrzej Kotela

    (Faculty of Medicine, Collegium Medicum, Cardinal Stefan Wyszynski University in Warsaw, Woycickiego 1/3, 01-938 Warsaw, Poland)

Abstract

(1) Background: Avascular necrosis (AVN) may affect every part of the bone. Epiphyseal infarcts are likely to be treated early because most are symptomatic. However, meta- and diaphyseal infarcts are silent and are diagnosed incidentally. Sarcomas developing in the necrotic bone are extremely rare, but they have been reported in the literature. (2) Methods: We conducted a mapping review of recent evidence regarding these malignancies. Methods: A mapping review using a systematic search strategy was conducted to answer research questions. We limited our research to the last ten years (2012–2022). (3) Results: A total of 11 papers were identified, including 9 case reports and 3 case series. The pathomechanism of carcinogenesis in AVN was not investigated to date. Histologically, most tumors were malignant fibrous histiocytoma. The prognosis is relatively poor, especially for patients with metastases, but adjuvant chemotherapy may increase short- and long-term survival. (4) Conclusions: Since AVN-related malignancies are sporadic, no prospective studies have been conducted. The majority of evidence comes from small case series. More research is needed to identify the risk factors that would justify follow-up of patients after bone infarcts at higher risk of developing a malignancy.

Suggested Citation

  • Wojciech Konarski & Tomasz Poboży & Martyna Hordowicz & Andrzej Śliwczyński & Ireneusz Kotela & Jan Krakowiak & Andrzej Kotela, 2022. "Bone Infarcts and Tumorigenesis—Is There a Connection? A Mini-Mapping Review," IJERPH, MDPI, vol. 19(15), pages 1-15, July.
    • Handle: RePEc:gam:jijerp:v:19:y:2022:i:15:p:9282-:d:875117
    as

    Download full text from publisher

    File URL: https://www.mdpi.com/1660-4601/19/15/9282/pdf
    Download Restriction: no
    File URL: https://www.mdpi.com/1660-4601/19/15/9282/
    Download Restriction: no
    ---><---

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Wojciech Konarski & Tomasz Poboży & Andrzej Kotela & Andrzej Śliwczyński & Ireneusz Kotela & Martyna Hordowicz & Jan Krakowiak, 2022. "Does Diabetes Mellitus Increase the Risk of Avascular Osteonecrosis? A Systematic Review and Meta-Analysis," IJERPH, MDPI, vol. 19(22), pages 1-9, November.

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:gam:jijerp:v:19:y:2022:i:15:p:9282-:d:875117. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: MDPI Indexing Manager (email available below). General contact details of provider: https://www.mdpi.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.