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Treatment and Prognosis of Oral Cancer Patients with Confirmed Contralateral Neck Metastasis: A Multicenter Retrospective Analysis

Author

Listed:
  • Yuki Sakamoto

    (Department of Dentistry and Oral Surgery, Kansai Medical University Medical Center, Moriguchi 570-8507, Japan)

  • Mitsunobu Otsuru

    (Department of Clinical Oral Oncology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki 852-8588, Japan)

  • Takumi Hasegawa

    (Department of Oral and Maxillofacial Surgery, Kobe University Graduate School of Medicine, Kobe 652-0032, Japan)

  • Masaya Akashi

    (Department of Oral and Maxillofacial Surgery, Kobe University Graduate School of Medicine, Kobe 652-0032, Japan)

  • Shin-ichi Yamada

    (Department of Oral and Maxillofacial Surgery, Faculty of Medicine, Academic Assembly, University of Toyama, Toyama 930-8555, Japan)

  • Hiroshi Kurita

    (Department of Dentistry and Oral Surgery, Shinshu University School of Medicine, Matsumoto 390-8621, Japan)

  • Masaya Okura

    (Department of Oral and Maxillofacial Surgery, Saiseikai Matsusaka General Hospital, Matsusaka 515-8557, Japan)

  • Nobuhiro Yamakawa

    (Department of Oral and Maxillofacial Surgery, Nara Medical University, Kashihara 634-8521, Japan)

  • Tadaaki Kirita

    (Department of Oral and Maxillofacial Surgery, Nara Medical University, Kashihara 634-8521, Japan)

  • Souichi Yanamoto

    (Department of Oral Oncology, Hiroshima University, Hiroshima 739-8511, Japan)

  • Masahiro Umeda

    (Department of Clinical Oral Oncology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki 852-8588, Japan)

  • Yuka Kojima

    (Department of Dentistry and Oral Surgery, Kansai Medical University, Hirakata 573-1191, Japan)

Abstract

The prognosis of oral cancer that has metastasized to the contralateral cervical lymph nodes is poor, although the appropriate treatment method has not been established because of its rarity. A multicenter retrospective study on the treatment and prognosis of pN2c oral cancer patients was conducted. We investigated the treatment and prognosis of 62 pN2c patients out of 388 pN+ patients with oral squamous cell carcinomas. Statistical analysis was performed on the various factors with overall survival (OS) and disease specific survival (DSS). In multivariate cox regression analysis, advanced T stage was significantly correlated with poor OS ( p = 0.011) and DSS ( p = 0.023) of patients with pN2c neck. In pN2c patients, OS, DSS, and neck control was not different between those undergoing ipsilateral neck dissection initially and those undergoing bilateral neck dissection. Thus, contralateral elective neck dissection is not recommended. The most important risk factor for prognosis in pN2c oral cancer patients is advanced T stage. No evidence was found to recommend contralateral elective neck dissection in clinically N1/2b patients. Therefore, the indication for contralateral elective neck dissection in N1/2b patients should be carefully determined in consideration of individual conditions.

Suggested Citation

  • Yuki Sakamoto & Mitsunobu Otsuru & Takumi Hasegawa & Masaya Akashi & Shin-ichi Yamada & Hiroshi Kurita & Masaya Okura & Nobuhiro Yamakawa & Tadaaki Kirita & Souichi Yanamoto & Masahiro Umeda & Yuka Ko, 2022. "Treatment and Prognosis of Oral Cancer Patients with Confirmed Contralateral Neck Metastasis: A Multicenter Retrospective Analysis," IJERPH, MDPI, vol. 19(15), pages 1-12, July.
    • Handle: RePEc:gam:jijerp:v:19:y:2022:i:15:p:9229-:d:874180
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