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Correlation of Salivary Occult Blood with the Plasma Concentration of Branched-Chain Amino Acids: A Cross-Sectional Study

Author

Listed:
  • Maya Izumi

    (School of Oral Health Sciences, Faculty of Dentistry, Kyushu Dental University, Kitakyushu 803-8580, Japan)

  • Kazuo Sonoki

    (School of Oral Health Sciences, Faculty of Dentistry, Kyushu Dental University, Kitakyushu 803-8580, Japan)

  • Sumio Akifusa

    (School of Oral Health Sciences, Faculty of Dentistry, Kyushu Dental University, Kitakyushu 803-8580, Japan)

Abstract

Background: Plasma branched-chain amino acids (BCAA) levels are predictors of glycometabolic disorders, leading to diabetes. Microbes, including periodontal pathogens, are thought to be associated with elevated plasma BCAA levels. This study aimed to evaluate the relationship between salivary occult blood (SOB) and plasma BCAA levels in middle-aged Japanese individuals. Methods: Sixty-four Japanese individuals aged ≥ 40 years were recruited for this study, which was conducted in Fukuoka Prefecture, Japan, from August to December 2021. Individuals diagnosed with and/or treated for diabetes were excluded from the study. The body mass index (BMI); plasma concentrations of total, high-density, and low-density lipoprotein cholesterol; triglyceride, glucose, and BCAA; and glycosylated hemoglobin ratio were measured. A basic periodontal examination was performed after the SOB test. Results: The median age of participants (men—20; women—44) was 55 (range, 41–78) years. The plasma BCAA concentration in the SOB-positive group (477 [400–658] μmol/L) was higher than that in the SOB-negative group (432 [307–665] μmol/L). Linear regression analysis revealed that SOB remained independently associated with the plasma BCAA level with statistical significance (β = 0.17, p = 0.02) after adjusting for sex, age, and BMI. Conclusions: SOB was positively correlated with plasma BCAA levels in middle-aged Japanese individuals. Thus, SOB may be a predictor of elevated plasma BCAA levels.

Suggested Citation

  • Maya Izumi & Kazuo Sonoki & Sumio Akifusa, 2022. "Correlation of Salivary Occult Blood with the Plasma Concentration of Branched-Chain Amino Acids: A Cross-Sectional Study," IJERPH, MDPI, vol. 19(15), pages 1-7, July.
    • Handle: RePEc:gam:jijerp:v:19:y:2022:i:15:p:8930-:d:869288
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    References listed on IDEAS

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    1. Helle Krogh Pedersen & Valborg Gudmundsdottir & Henrik Bjørn Nielsen & Tuulia Hyotylainen & Trine Nielsen & Benjamin A. H. Jensen & Kristoffer Forslund & Falk Hildebrand & Edi Prifti & Gwen Falony & E, 2016. "Human gut microbes impact host serum metabolome and insulin sensitivity," Nature, Nature, vol. 535(7612), pages 376-381, July.
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