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Novel Options to Counteract Oral Biofilm Formation: In Vitro Evidence

Author

Listed:
  • Alessandra Odorici

    (School of Doctorate in Clinical and Experimental Medicine, Laboratory of Microbiology and Virology, University of Modena and Reggio Emilia, Via G. Campi 287, 41125 Modena, Italy)

  • Bruna Colombari

    (Department of Surgery, Medicine, Dentistry and Morphological Sciences with Interest in Transplant, Oncology and Regenerative Medicine, Laboratory of Microbiology and Virology, University of Modena and Reggio Emilia, Via G. Campi 287, 41125 Modena, Italy)

  • Pierantonio Bellini

    (Department of Surgery, Medicine, Dentistry and Morphological Sciences with Interest in Transplant, Oncology and Regenerative Medicine, Laboratory of Microbiology and Virology, University of Modena and Reggio Emilia, Via G. Campi 287, 41125 Modena, Italy)

  • Aida Meto

    (Department of Dentistry, Faculty of Dental Sciences, University of Aldent, 1007 Tirana, Albania
    Department of Dentistry, Faculty of Dental Medicine, University of Western Balkans, 1051 Tirana, Albania)

  • Irene Venturelli

    (School of Specialization in Microbiology and Virology, University of Modena and Reggio Emilia, Via G. Campi 287, 41125 Modena, Italy)

  • Elisabetta Blasi

    (Department of Surgery, Medicine, Dentistry and Morphological Sciences with Interest in Transplant, Oncology and Regenerative Medicine, Laboratory of Microbiology and Virology, University of Modena and Reggio Emilia, Via G. Campi 287, 41125 Modena, Italy)

Abstract

Biofilm production on biotic and abiotic surfaces is crucial in the pathogenesis of most infections, particularly those occurring in the oral cavity. Its prevention and/or control may greatly facilitate the management of patients with oral diseases. Here, the antibiofilm activity of a biomimetic hydroxyapatite and a natural compound, MicroRepair (MicroR) and pomegranate (PomeGr), respectively, was assessed. By luminescence/fluorescence-based assays, Pseudomonas aeruginosa ( P. aeruginosa ), Staphylococcus aureus ( S. aureus ) and Candida albicans ( C. albicans ) were tested for biofilm production in the presence of MicroR and/or PomeGr. We found that both MicroR and PomeGr could affected biofilm production; however, the efficacy of the two, given alone or in combination, varied according to the microbial agent considered. These data open to clinical studies aimed at defining the most efficacious protocols to counteract oral biofilm-associated infections.

Suggested Citation

  • Alessandra Odorici & Bruna Colombari & Pierantonio Bellini & Aida Meto & Irene Venturelli & Elisabetta Blasi, 2022. "Novel Options to Counteract Oral Biofilm Formation: In Vitro Evidence," IJERPH, MDPI, vol. 19(13), pages 1-6, June.
    • Handle: RePEc:gam:jijerp:v:19:y:2022:i:13:p:8056-:d:852832
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