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Transcription Factor AhR, Cytokines IL-6 and IL-22 in Subjects with and without Peri-Implantitis: A Case Control-Study

Author

Listed:
  • Luis Ricardo Linard Martins

    (Department of Periodontology, Dental Research Division, Guarulhos University, Guarulhos 07023-070, Brazil
    These authors contributed equally to this work.)

  • Kinga Grzech-Leśniak

    (Laser Laboratory at Dental Surgery Department, Medical University of Wroclaw, 50-425 Wroclaw, Poland
    These authors contributed equally to this work.)

  • Nidia Castro dos Santos

    (Department of Periodontology, Dental Research Division, Guarulhos University, Guarulhos 07023-070, Brazil
    Center for Clinical and Translational Research, The Forsyth Institute, Cambridge, MA 02142, USA)

  • Lina J. Suárez

    (Department of Periodontology, Dental Research Division, Guarulhos University, Guarulhos 07023-070, Brazil
    Departamento de Ciencias Básicas y Medicina Oral, Universidad Nacional de Colombia, Cra 45 # 26-85, Bogota 11001, Colombia)

  • Gabriela Giro

    (Department of Periodontology, Dental Research Division, Guarulhos University, Guarulhos 07023-070, Brazil)

  • Marta Ferreira Bastos

    (Programa de Pós Graduação em Ciências do Envelhecimento, Universidade São Judas Tadeu, Rua Taquari, 546, Sao Paulo 03166-000, Brazil)

  • Jamil Awad Shibli

    (Department of Periodontology, Dental Research Division, Guarulhos University, Guarulhos 07023-070, Brazil)

Abstract

Peri-implantitis is a plaque-associated condition characterized by mucosal inflammation and subsequent progressive loss of supporting bone; it is caused by bacterial biofilm, but the host response triggered by bacterial stimulation promotes the release of cells and mediators that culminate in tissue destruction. The Aryl-hydrocarbon Receptor (AhR) is associated with IL-22 production by Th22 and Th17 CD4+ Th cells. The presence of IL-6 may promote the Th22 phenotype. The present case-control study evaluated the gene expression of AhR, IL-22, and IL-6 in the peri-implant tissues of healthy and peri-implantitis patients. Tissue biopsies were collected from thirty-five volunteers (15 healthy and 20 with peri-implantitis). A real-time PCR reaction was utilized to assess the AhR, IL-22, and IL-6 gene expression levels relative to the reference gene (GAPDH). The results were analyzed using the Mann–Whitney test with a significance level of 5%. Higher levels of gene expression of AhR and IL-6 were detected in peri-implantitis tissues. The IL-22 gene expression levels did not differ between groups. In conclusion, higher gene expression levels for AhR and IL-6 were detected in the soft tissues of peri-implantitis patients. IL-22 did not vary between conditions, which may indicate the loss of the immunomodulatory role of IL-22 in periimplantitis.

Suggested Citation

  • Luis Ricardo Linard Martins & Kinga Grzech-Leśniak & Nidia Castro dos Santos & Lina J. Suárez & Gabriela Giro & Marta Ferreira Bastos & Jamil Awad Shibli, 2022. "Transcription Factor AhR, Cytokines IL-6 and IL-22 in Subjects with and without Peri-Implantitis: A Case Control-Study," IJERPH, MDPI, vol. 19(12), pages 1-10, June.
    • Handle: RePEc:gam:jijerp:v:19:y:2022:i:12:p:7434-:d:841185
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    References listed on IDEAS

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    1. Alban Bessede & Marco Gargaro & Maria T. Pallotta & Davide Matino & Giuseppe Servillo & Cinzia Brunacci & Silvio Bicciato & Emilia M. C. Mazza & Antonio Macchiarulo & Carmine Vacca & Rossana Iannitti , 2014. "Aryl hydrocarbon receptor control of a disease tolerance defence pathway," Nature, Nature, vol. 511(7508), pages 184-190, July.
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