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A Systematic Review and Meta-Analysis of Systemic Antibiotic Therapy in the Treatment of Peri-Implantitis

Author

Listed:
  • Manuel Toledano-Osorio

    (Department of Stomatology, Faculty of Dentistry, University of Granada, Colegio Máximo de Cartuja s/n, 18071 Granada, Spain)

  • Cristina Vallecillo

    (Department of Stomatology, Faculty of Dentistry, University of Granada, Colegio Máximo de Cartuja s/n, 18071 Granada, Spain)

  • Raquel Toledano

    (Independent Researcher, 18071 Granada, Spain)

  • Fátima S. Aguilera

    (Department of Stomatology, Faculty of Dentistry, University of Granada, Colegio Máximo de Cartuja s/n, 18071 Granada, Spain)

  • María T. Osorio

    (Independent Researcher, 18071 Granada, Spain)

  • Esther Muñoz-Soto

    (Department of Stomatology, Faculty of Dentistry, University of Granada, Colegio Máximo de Cartuja s/n, 18071 Granada, Spain)

  • Franklin García-Godoy

    (Health Science Center, College of Dentistry, University of Tennessee, 875 Union Avenue, Memphis, TN 38103, USA)

  • Marta Vallecillo-Rivas

    (Department of Stomatology, Faculty of Dentistry, University of Granada, Colegio Máximo de Cartuja s/n, 18071 Granada, Spain)

Abstract

Research has been conducted into the advantages of the systemic administration of antibiotics. The aim of this systematic review and meta-analysis was to assess the efficacy of systemic antibiotic administration in the treatment of peri-implantitis in terms of bleeding on probing (BoP) and probing pocket depth (PPD). Literature searches were performed across PubMed, EMBASE, and Cochrane Central Register of Controlled Trials (CENTRAL) to identify randomized controlled trials and observational clinical studies. After peri-implantitis treatment, PPD was reduced by 0.1 mm ( p = 0.58; IC 95% [−0.24, 0.47]), indicating a non-significant effect of antibiotic administration on PPD. The BoP odds ratio value was 1.15 ( p = 0.5; IC 95% [0.75, 1.75]), indicating that the likelihood of bleeding is almost similar between the test and control groups. Secondary outcomes were found, such as reduced clinical attachment level, lower suppuration and recession, less bone loss, and a reduction in total bacterial counts. In the treatment of peri-implantitis, the systemic antibiotic application reduces neither PPD nor BoP. Therefore, the systemic administration of antibiotics, in the case of peri-implantitis, should be rethought in light of the present results, contributing to address the problem of increasing antibiotic resistance.

Suggested Citation

  • Manuel Toledano-Osorio & Cristina Vallecillo & Raquel Toledano & Fátima S. Aguilera & María T. Osorio & Esther Muñoz-Soto & Franklin García-Godoy & Marta Vallecillo-Rivas, 2022. "A Systematic Review and Meta-Analysis of Systemic Antibiotic Therapy in the Treatment of Peri-Implantitis," IJERPH, MDPI, vol. 19(11), pages 1-25, May.
    • Handle: RePEc:gam:jijerp:v:19:y:2022:i:11:p:6502-:d:825114
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    Cited by:

    1. Carlos M. Ardila & Annie Marcela Vivares-Builes, 2022. "Antibiotic Resistance in Patients with Peri-Implantitis: A Systematic Scoping Review," IJERPH, MDPI, vol. 19(23), pages 1-10, November.

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