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Effects of Commercial Probiotics on Colonic Sensitivity after Acute Mucosal Irritation

Author

Listed:
  • Laura López-Gómez

    (Department of Basic Health Sciences, University Rey Juan Carlos (URJC), 28922 Alcorcón, Spain
    High Performance Research Group in Physiopathology and Pharmacology of the Digestive System (NeuGut-URJC), University Rey Juan Carlos, 28922 Alcorcón, Spain)

  • Jaime Antón

    (Department of Basic Health Sciences, University Rey Juan Carlos (URJC), 28922 Alcorcón, Spain)

  • Yolanda López-Tofiño

    (Department of Basic Health Sciences, University Rey Juan Carlos (URJC), 28922 Alcorcón, Spain
    High Performance Research Group in Physiopathology and Pharmacology of the Digestive System (NeuGut-URJC), University Rey Juan Carlos, 28922 Alcorcón, Spain)

  • Bianca Pomana

    (Department of Basic Health Sciences, University Rey Juan Carlos (URJC), 28922 Alcorcón, Spain)

  • José A. Uranga

    (Department of Basic Health Sciences, University Rey Juan Carlos (URJC), 28922 Alcorcón, Spain
    High Performance Research Group in Physiopathology and Pharmacology of the Digestive System (NeuGut-URJC), University Rey Juan Carlos, 28922 Alcorcón, Spain)

  • Raquel Abalo

    (Department of Basic Health Sciences, University Rey Juan Carlos (URJC), 28922 Alcorcón, Spain
    High Performance Research Group in Physiopathology and Pharmacology of the Digestive System (NeuGut-URJC), University Rey Juan Carlos, 28922 Alcorcón, Spain
    Associated I+D+i Unit to the Institute of Medicinal Chemistry (IQM), Scientific Research Superior Council (CSIC), 28006 Madrid, Spain
    Working Group of Basic Sciences in Pain and Analgesia of the Spanish Society of Pain, 28046 Madrid, Spain)

Abstract

Gastrointestinal pathologies associated with abdominal pain, such as irritable bowel syndrome or inflammatory bowel disease, lack sufficiently effective treatments. In our study we have used a rat model of visceral pain (72 animals; n = 8–13 per experimental group) to analyze the consequences of intracolonic administration of the irritant acetic acid on visceral sensitivity, histology of the colonic wall, and inflammatory response. Moreover, we have studied the possible beneficial effects of a pretreatment with a commercial probiotic (Actimel ® ). Contrary to expectations, acetic acid application (7 cm proximal to the anus) decreased the nociceptive response to intracolonic mechanical stimulation, with a slight increase in the histological damage of colonic mucosa. The intensity of these changes depended on the concentration (4% or 0.6%) and the time of application (30 or 60 min). Pretreatment with probiotics (by daily gavage, for 1 week) normalized the values obtained in the visceral sensitivity test but revealed an increase in the number of macrophages. These results suggest a possible activation of inhibitory mechanisms early after colonic irritation, not previously described (which need further experimental confirmation), and the ability of probiotics to normalize the effects of acetic acid. In addition, pretreatment with probiotics has a direct effect on immune functions, stimulating macrophagic activity.

Suggested Citation

  • Laura López-Gómez & Jaime Antón & Yolanda López-Tofiño & Bianca Pomana & José A. Uranga & Raquel Abalo, 2022. "Effects of Commercial Probiotics on Colonic Sensitivity after Acute Mucosal Irritation," IJERPH, MDPI, vol. 19(11), pages 1-22, May.
  • Handle: RePEc:gam:jijerp:v:19:y:2022:i:11:p:6485-:d:824901
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