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Rapid Assessment of Oxidative Damage Potential: A Comparative Study of Engineered Stone Dusts Using a Deoxyguanosine Assay

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Listed:
  • Leigh Thredgold

    (Adelaide Exposure Science and Health, School of Public Health, University of Adelaide, Adelaide, SA 5005, Australia)

  • Chandnee Ramkissoon

    (Adelaide Exposure Science and Health, School of Public Health, University of Adelaide, Adelaide, SA 5005, Australia)

  • Chellan Kumarasamy

    (Adelaide Exposure Science and Health, School of Public Health, University of Adelaide, Adelaide, SA 5005, Australia)

  • Richard Gun

    (Adelaide Exposure Science and Health, School of Public Health, University of Adelaide, Adelaide, SA 5005, Australia)

  • Shelley Rowett

    (SafeWork SA, Government of South Australia, Adelaide, SA 5035, Australia)

  • Sharyn Gaskin

    (Adelaide Exposure Science and Health, School of Public Health, University of Adelaide, Adelaide, SA 5005, Australia)

Abstract

The popularity of engineered stone (ES) has been associated with a global increase in occupational lung disease in workers exposed to respirable dust during the fabrication of benchtops and other ES products. In this study, the reactivity and subsequent oxidative reduction potential of freshly generated ES dusts were evaluated by (i) comparing different engineered and natural stones, (ii) comparing settled and respirable stone dust fractions and (iii) assessing the effect of ageing on the reactivity of freshly generated stone dust. An established cell-free deoxyguanosine hydroxylation assay was used to assess the potential for oxidative DNA damage. ES dust exhibited a higher relative reactivity than two of the three natural stones tested. Respirable dust fractions were found to be significantly more reactive than their corresponding settled fraction (ANOVA, p < 0.05) across all stone types and samples. However, settled dust still displayed high relative reactivity. The lower reactivity of the settled dust was not due to decay in reactivity of the respirable dust when it settled but rather a result of the admixture of larger nonrespirable particles. No significant change in respirable dust reactivity was observed for three ES samples over a 21-day time period, whereas a significant decrease in reactivity was observed in the natural stone studied. This study has practical implications for dust control and housekeeping in industry, risk assessment and hazard management.

Suggested Citation

  • Leigh Thredgold & Chandnee Ramkissoon & Chellan Kumarasamy & Richard Gun & Shelley Rowett & Sharyn Gaskin, 2022. "Rapid Assessment of Oxidative Damage Potential: A Comparative Study of Engineered Stone Dusts Using a Deoxyguanosine Assay," IJERPH, MDPI, vol. 19(10), pages 1-10, May.
    • Handle: RePEc:gam:jijerp:v:19:y:2022:i:10:p:6221-:d:819996
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    References listed on IDEAS

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    1. Veruscka Leso & Luca Fontana & Rosaria Romano & Paola Gervetti & Ivo Iavicoli, 2019. "Artificial Stone Associated Silicosis: A Systematic Review," IJERPH, MDPI, vol. 16(4), pages 1-17, February.
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