IDEAS home Printed from https://ideas.repec.org/a/gam/jijerp/v19y2021i1p439-d715753.html
   My bibliography  Save this article

Neurovascular Impairment and Therapeutic Strategies in Diabetic Retinopathy

Author

Listed:
  • Toshiyuki Oshitari

    (Department of Ophthalmology and Visual Science, Chiba University Graduate School of Medicine, Inohana 1-8-1, Chuo-ku, Chiba 260-8670, Japan
    Department of Ophthalmology, International University of Health and Welfare School of Medicine, 4-3 Kozunomori, Narita 286-8686, Japan)

Abstract

Diabetic retinopathy has recently been defined as a highly specific neurovascular complication of diabetes. The chronic progression of the impairment of the interdependence of neurovascular units (NVUs) is associated with the pathogenesis of diabetic retinopathy. The NVUs consist of neurons, glial cells, and vascular cells, and the interdependent relationships between these cells are disturbed under diabetic conditions. Clinicians should understand and update the current knowledge of the neurovascular impairments in diabetic retinopathy. Above all, neuronal cell death is an irreversible change, and it is directly related to vision loss in patients with diabetic retinopathy. Thus, neuroprotective and vasoprotective therapies for diabetic retinopathy must be established. Understanding the physiological and pathological interdependence of the NVUs is helpful in establishing neuroprotective and vasoprotective therapies for diabetic retinopathy. This review focuses on the pathogenesis of the neurovascular impairments and introduces possible neurovascular protective therapies for diabetic retinopathy.

Suggested Citation

  • Toshiyuki Oshitari, 2021. "Neurovascular Impairment and Therapeutic Strategies in Diabetic Retinopathy," IJERPH, MDPI, vol. 19(1), pages 1-19, December.
    • Handle: RePEc:gam:jijerp:v:19:y:2021:i:1:p:439-:d:715753
    as

    Download full text from publisher

    File URL: https://www.mdpi.com/1660-4601/19/1/439/pdf
    Download Restriction: no
    File URL: https://www.mdpi.com/1660-4601/19/1/439/
    Download Restriction: no
    ---><---

    References listed on IDEAS

    as
    1. Xiaofei Chen & Chuang Nie & Yan Gong & Ying Zhang & Xin Jin & Shihui Wei & Maonian Zhang, 2015. "Peripapillary Retinal Nerve Fiber Layer Changes in Preclinical Diabetic Retinopathy: A Meta-Analysis," PLOS ONE, Public Library of Science, vol. 10(5), pages 1-12, May.
    Full references (including those not matched with items on IDEAS)

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.

      Corrections

      All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:gam:jijerp:v:19:y:2021:i:1:p:439-:d:715753. See general information about how to correct material in RePEc.

      If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

      If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

      If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

      For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: MDPI Indexing Manager (email available below). General contact details of provider: https://www.mdpi.com .

      Please note that corrections may take a couple of weeks to filter through the various RePEc services.

      IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.