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Senescence-Mediated Redox Imbalance in Liver and Kidney: Antioxidant Rejuvenating Potential of Green Tea Extract

Author

Listed:
  • Yu-Wen Hsu

    (Department of Optometry, Da-Yeh University, Changhua 515006, Taiwan)

  • Wen-Kang Chen

    (Department of Applied Cosmetology, National Tainan Junior College of Nursing, Tainan 700007, Taiwan)

  • Chia-Fang Tsai

    (Department of Applied Cosmetology, National Tainan Junior College of Nursing, Tainan 700007, Taiwan)

Abstract

This study investigates the catechin composition and protective effect of green tea extract on senescence-mediated redox imbalance in the livers and kidneys of aged mice. The results showed that the seven catechins in the green tea extract analyzed in this study could be completely separated within 30 min and the main components of catechins in green tea extract were EGCG, EGC and ECG. In terms of the anti-senescence effects of green tea extract, green tea extract supplementation at doses of 125, 625 and 1250 mg/kg for 4 weeks significantly alleviated the senescence-mediated redox imbalance, as exhibited from significantly ( p < 0.05) reduced thiobarbituric acid-reactive substances (TBARS) and protein carbonyls levels in the serum, and increased glutathione (GSH) and total thiols contents in the plasma. Additionally, hepatic and renal protein carbonyls levels were significantly diminished ( p < 0.05) and the activities of superoxide dismutase (SOD), catalase, glucose-6-phosphate dehydrogenase (G6PD), glutathione peroxidase (GSH-Px) and glutathione reductase (GSH-Rd) in the liver and kidney were remarkably elevated ( p < 0.05). Overall, these results clearly show that green tea extract exhibits extremely potent protective effects against senescence-mediated redox imbalance in the livers and kidneys of mice by inhibiting oxidative damage of lipids and proteins and increasing the activities of antioxidant enzymes in organs.

Suggested Citation

  • Yu-Wen Hsu & Wen-Kang Chen & Chia-Fang Tsai, 2021. "Senescence-Mediated Redox Imbalance in Liver and Kidney: Antioxidant Rejuvenating Potential of Green Tea Extract," IJERPH, MDPI, vol. 19(1), pages 1-15, December.
    • Handle: RePEc:gam:jijerp:v:19:y:2021:i:1:p:260-:d:711803
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