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Vitamin D and Depressive Symptoms in Adults with Multiple Sclerosis: A Scoping Review

Author

Listed:
  • Carmen Concerto

    (Psychiatry Unit, Department of Clinical and Experimental Medicine, University of Catania, 95123 Catania, Italy)

  • Alessandro Rodolico

    (Psychiatry Unit, Department of Clinical and Experimental Medicine, University of Catania, 95123 Catania, Italy)

  • Alessia Ciancio

    (Psychiatry Unit, Department of Clinical and Experimental Medicine, University of Catania, 95123 Catania, Italy)

  • Christian Messina

    (MS Center, Department “G.F. Ingrassia”, University of Catania, Via Santa Sofia 78, 95123 Catania, Italy)

  • Antimo Natale

    (Psychiatry Unit, Department of Clinical and Experimental Medicine, University of Catania, 95123 Catania, Italy)

  • Ludovico Mineo

    (Psychiatry Unit, Department of Clinical and Experimental Medicine, University of Catania, 95123 Catania, Italy)

  • Fortunato Battaglia

    (Department of Medical Sciences, Neurology and Psychiatry, Hackensack Meridian School of Medicine, Nutley, NJ 07110, USA)

  • Eugenio Aguglia

    (Psychiatry Unit, Department of Clinical and Experimental Medicine, University of Catania, 95123 Catania, Italy)

Abstract

Background. Vitamin D deficiency has been correlated with Multiple Sclerosis (MS) risk and disease activity. There is some controversy as to whether vitamin D could have an impact on depressive symptoms in people with MS (pwMS). The aim of this scoping review was to evaluate the association between vitamin D status and depressive symptoms in pwMS. Methods. We searched databases to include studies published up to March 2021 to provide an overview of the available evidence on the correlation between vitamin D status and depressive symptoms in pwMS. The eligibility criteria were as follows: studies evaluating the use of vitamin D measurement on depressive symptoms in patients suffering from MS, including randomized and non-randomized studies; studies written in English; and studies exploring an adult population over the age of 18. Results. Eleven studies met our inclusion criteria: two of them were abstracts only; the majority were cross-sectional studies; two were prospective longitudinal studies; one was a retrospective cohort study; and one was a randomized placebo-controlled trial (RCT). Of the eleven studies selected, seven showed a potential correlation between low vitamin D levels and depressive symptoms. Conclusion. Future RCT studies should include patients with greater severity of depressive symptoms and should consider confounding factors such as sun exposure and seasonal variation of vitamin D.

Suggested Citation

  • Carmen Concerto & Alessandro Rodolico & Alessia Ciancio & Christian Messina & Antimo Natale & Ludovico Mineo & Fortunato Battaglia & Eugenio Aguglia, 2021. "Vitamin D and Depressive Symptoms in Adults with Multiple Sclerosis: A Scoping Review," IJERPH, MDPI, vol. 19(1), pages 1-21, December.
    • Handle: RePEc:gam:jijerp:v:19:y:2021:i:1:p:199-:d:711012
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    References listed on IDEAS

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    1. Marco Cambiaghi & Rosalia Crupi & Erick Larios Bautista & Amir Elsamadisi & Wasib Malik & Helen Pozdniakova & Zhiyong Han & Mario Buffelli & Fortunato Battaglia, 2020. "The Effects of 1-Hz rTMS on Emotional Behavior and Dendritic Complexity of Mature and Newly Generated Dentate Gyrus Neurons in Male Mice," IJERPH, MDPI, vol. 17(11), pages 1-11, June.
    2. Carmenrita Infortuna & Francesco Gratteri & Andrew Benotakeia & Sapan Patel & Alex Fleischman & Maria Rosaria Anna Muscatello & Antonio Bruno & Rocco Antonio Zoccali & Eileen Chusid & Zhiyong Han & Fo, 2020. "Exploring the Gender Difference and Predictors of Perceived Stress among Students Enrolled in Different Medical Programs: A Cross-Sectional Study," IJERPH, MDPI, vol. 17(18), pages 1-8, September.
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