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A Case of Silicone and Sarcoid Granulomas in a Patient with “Highly Cohesive” Silicone Breast Implants: A Histopathologic and Laser Raman Microprobe Analysis

Author

Listed:
  • Todor I. Todorov

    (Department of Environmental and Infectious Disease Sciences, Division of Biophysical Toxicology, Armed Forces Institute of Pathology, Washington, DC 20306, USA
    Current address: Center for Food Safety and Applied Nutrition, US Food and Drug Administration, College Park, MD 20740, USA.)

  • Erik de Bakker

    (Department of Plastic Surgery, VU University Medical Centre, P.O. Box 7057, 1007 MB Amsterdam, The Netherlands
    Department of Molecular Cell Biology and Immunology, VU University Medical Centre, P.O. Box 7057, 1007 MB Amsterdam, The Netherlands)

  • Diane Smith

    (Henry Jackson Foundation, Bethesda, MD 20817, USA
    Current address: Center for Device and Radiological Health, US Food and Drug Administration, Silver Spring, MD 20993, USA.)

  • Lisette C. Langenberg

    (Department of Internal Medicine, VU University Medical Centre, P.O. Box 7057, 1007 MB Amsterdam, The Netherlands)

  • Linda A. Murakata

    (Department of Environmental and Infectious Disease Sciences, Division of Biophysical Toxicology, Armed Forces Institute of Pathology, Washington, DC 20306, USA
    Current address: South Jersey Gastroenterology, Marlton, NJ 08053, USA.)

  • Mark H. H. Kramer

    (Department of Pathology, VU University Medical Centre, P.O. Box 7057, 1007 MB Amsterdam, The Netherlands)

  • Jose A. Centeno

    (Department of Environmental and Infectious Disease Sciences, Division of Biophysical Toxicology, Armed Forces Institute of Pathology, Washington, DC 20306, USA
    Current address: Division of Occupational and Environmental Medicine, University of Maryland School of Medicine, Baltimore, MD 21201, USA.)

  • Prabath W. B. Nanayakkara

    (Henry Jackson Foundation, Bethesda, MD 20817, USA)

Abstract

Foreign body giant cell (FBGC) reaction to silicone material in the lymph nodes of patients with silicone breast implants has been documented in the literature, with a number of case reports dating back to 1978. Many of these case reports describe histologic features of silicone lymphadenopathy in regional lymph nodes from patients with multiple sets of different types of implants, including single lumen smooth surface gel, single lumen textured surface gel, single lumen with polyethylene terephthalate patch, single lumen with polyurethane coating, and double lumen smooth surface. Only one other case report described a patient with highly-cohesive breast implants and silicone granulomas of the skin. In this article, we describe a patient with a clinical presentation of systemic sarcoidosis following highly cohesive breast implant placement. Histopathologic analysis and Confocal Laser Raman Microprobe (CLRM) examination were used to confirm the presence of silicone in the axillary lymph node and capsular tissues. This is the first report where chemical spectroscopic mapping has been used to establish and identify the coexistence of Schaumann bodies, consisting of calcium oxalate and calcium phosphate minerals, together with silicone implant material.

Suggested Citation

  • Todor I. Todorov & Erik de Bakker & Diane Smith & Lisette C. Langenberg & Linda A. Murakata & Mark H. H. Kramer & Jose A. Centeno & Prabath W. B. Nanayakkara, 2021. "A Case of Silicone and Sarcoid Granulomas in a Patient with “Highly Cohesive” Silicone Breast Implants: A Histopathologic and Laser Raman Microprobe Analysis," IJERPH, MDPI, vol. 18(9), pages 1-11, April.
    • Handle: RePEc:gam:jijerp:v:18:y:2021:i:9:p:4526-:d:542653
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