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A Randomized Controlled Trial Comparing Two Doses of Caffeine for Apnoea in Prematurity

Author

Listed:
  • Anis Munirah Mohd Kori

    (Department of Paediatrics, Health Campus, School of Medical Sciences, Universiti Sains Malaysia, Kubang Kerian 16150, Kelantan, Malaysia
    Hospital USM, Universiti Sains Malaysia, Kubang Kerian 16150, Kelantan, Malaysia)

  • Hans Van Rostenberghe

    (Department of Paediatrics, Health Campus, School of Medical Sciences, Universiti Sains Malaysia, Kubang Kerian 16150, Kelantan, Malaysia
    Hospital USM, Universiti Sains Malaysia, Kubang Kerian 16150, Kelantan, Malaysia)

  • Nor Rosidah Ibrahim

    (Department of Paediatrics, Health Campus, School of Medical Sciences, Universiti Sains Malaysia, Kubang Kerian 16150, Kelantan, Malaysia
    Hospital USM, Universiti Sains Malaysia, Kubang Kerian 16150, Kelantan, Malaysia)

  • Najib Majdi Yaacob

    (Department of Biostatistics and Research Methodology, Health Campus, School of Medical Sciences, Universiti Sains Malaysia, Kubang Kerian 16150, Kelantan, Malaysia)

  • Ariffin Nasir

    (Department of Paediatrics, Health Campus, School of Medical Sciences, Universiti Sains Malaysia, Kubang Kerian 16150, Kelantan, Malaysia
    Hospital USM, Universiti Sains Malaysia, Kubang Kerian 16150, Kelantan, Malaysia)

Abstract

Caffeine is the most commonly used methyl xanthine for the prevention of apnoea in prematurity, but the ideal dose was uncertain, until now. This study compared two doses of caffeine for the prevention of apnoea in prematurity. A clinical trial was conducted on 78 preterm infants ≤32 weeks in Neonatal Intensive Care Unit. They were randomly allocated to receive the intervention (loading 40 mg/kg/day and maintenance of 20 mg/kg/day) or the control (loading 20 mg/kg/day and maintenance of 10 mg/kg/day) dose of caffeine. The primary outcome of the study was the frequency and total days of apnoea per duration of treatment for both groups. The frequency of apnoea ranged from zero to fourteen in the intervention group and zero to twelve in the control group. There was no statistically significant difference between the groups, with a p -value of 0.839. The number of days of apnoea was also similar between both groups, with a p -value of 0.928. There was also no significant difference in adverse events between both regimens. This study did not support the use of higher doses of caffeine as a prevention for apnoea in prematurity.

Suggested Citation

  • Anis Munirah Mohd Kori & Hans Van Rostenberghe & Nor Rosidah Ibrahim & Najib Majdi Yaacob & Ariffin Nasir, 2021. "A Randomized Controlled Trial Comparing Two Doses of Caffeine for Apnoea in Prematurity," IJERPH, MDPI, vol. 18(9), pages 1-8, April.
    • Handle: RePEc:gam:jijerp:v:18:y:2021:i:9:p:4509-:d:542355
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