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Development of a Questionnaire for the Search for Occupational Causes in Patients with Non-Hodgkin Lymphoma: The RHELYPRO Study

Author

Listed:
  • Mireille Matrat

    (Service des Pathologies Professionnelles et de l’Environnement, CHI Créteil, F-94010 Créteil, France)

  • Murielle Gain

    (Service des Pathologies Professionnelles et de l’Environnement, CHI Créteil, F-94010 Créteil, France)

  • Corinne Haioun

    (INSERM, IMRB, Paris Est Créteil University, F-94010 Créteil, France
    AP-HP, Hôpital Henri Mondor, Unité Hémopathies Lymphoïdes, F-94010 Créteil, France)

  • Fabien Le Bras

    (AP-HP, Hôpital Henri Mondor, Unité Hémopathies Lymphoïdes, F-94010 Créteil, France)

  • Catherine Nisse

    (CHU Lille, Institut Pasteur de Lille, Université de Lille, 4483-IMPECS-Impact de l’environnement Chimique sur la Santé Humaine, F-59000 Lille, France)

  • Franck Morschhauser

    (ULR 7365-GRITA-Groupe de Recherche sur les Formes Injectables et les Technologies Associées, Université de Lille, CHU Lille, F-59000 Lille, France)

  • Bénédicte Clin

    (Centre Régional de Pathologies Professionnelles et Environnementales, CHU de Caen, INSERM U1086, Cancers et Préventions, Université de Caen Normandie, F-14033 Caen, France)

  • Isabelle Baldi

    (Service Santé Travail Environnement, CHU Bordeaux, INSERM U1219, EPICENE, Bordeaux University, F-33076 Bordeaux, France)

  • Catherine Verdun-Esquer

    (Service Santé Travail Environnement, CHU Bordeaux, INSERM U1219, EPICENE, Bordeaux University, F-33076 Bordeaux, France)

  • Robert Garnier

    (Centre Antipoison de Paris, Consultation de Pathologie Professionnelle et de l’Environnement, AP-HP, Nord-Université de Paris, Hôpital Lariboisière-Fernand Widal-St Louis, F-75475 Paris, France)

  • Hervé Laborde-Castérot

    (Centre Antipoison de Paris, Consultation de Pathologie Professionnelle et de l’Environnement, AP-HP, Nord-Université de Paris, Hôpital Lariboisière-Fernand Widal-St Louis, F-75475 Paris, France)

  • Fabrice Hérin

    (Centre Régional de Pathologies Professionnelles et Environnementales, CHU Toulouse, F-31059 Toulouse, France)

  • Yolande Esquirol

    (Centre Régional de Pathologies Professionnelles et Environnementales, CHU Toulouse, F-31059 Toulouse, France)

  • Pascal Andujar

    (Service des Pathologies Professionnelles et de l’Environnement, CHI Créteil, F-94010 Créteil, France
    INSERM, IMRB, Paris Est Créteil University, F-94010 Créteil, France)

  • Milia Belacel

    (Institut Santé-Travail Paris-Est, CHI Créteil, F-94010 Créteil, France)

  • Christos Chouaïd

    (Centre de Recherche Clinique, CHI Créteil, F-94010 Créteil, France)

  • Claire Chauvet

    (Anses, Agence Nationale de Sécurité Sanitaire de l’alimentation, de l’environnement et du Travail, F-94700 Maisons-Alfort, France)

  • Gérard Lasfargues

    (Anses, Agence Nationale de Sécurité Sanitaire de l’alimentation, de l’environnement et du Travail, F-94700 Maisons-Alfort, France)

  • Jean-Claude Pairon

    (Service des Pathologies Professionnelles et de l’Environnement, CHI Créteil, F-94010 Créteil, France
    INSERM, IMRB, Paris Est Créteil University, F-94010 Créteil, France)

Abstract

Non-Hodgkin lymphoma (NHL), multiple myeloma and chronic lymphocytic leukemia are possibly related to environmental and/or occupational exposure. The primary objective of this study was to develop a questionnaire for screening patients with these blood disorders who might benefit from a specialized consultation for possible recognition of the disease as an occupational disease. The study included 205 subjects (male gender, 67.3%; mean age, 60 years; NHL, 78.5%). The questionnaire performed very satisfactorily in identifying the exposures most frequently retained by experts for their potential involvement in the occurrence of NHL. Its sensitivity and specificity in relation to the final expertise were 96% and 96% for trichloroethylene, 85% and 82% for benzene, 78% and 87% for solvents other than trichloroethylene and dichloromethane, 87% and 95% for pesticides, respectively. Overall, 15% of the subjects were invited to ask National Social Insurance for compensation as occupational disease. These declarations concerned exposure to pesticides (64%), solvents (trichloroethylene: 29%; benzene: 18%; other than chlorinated solvents: 18%) and sometimes multiple exposures. In conclusion, this questionnaire appears as a useful tool to identify NHL patients for a specialized consultation, in order to ask for compensation for occupational disease.

Suggested Citation

  • Mireille Matrat & Murielle Gain & Corinne Haioun & Fabien Le Bras & Catherine Nisse & Franck Morschhauser & Bénédicte Clin & Isabelle Baldi & Catherine Verdun-Esquer & Robert Garnier & Hervé Laborde-C, 2021. "Development of a Questionnaire for the Search for Occupational Causes in Patients with Non-Hodgkin Lymphoma: The RHELYPRO Study," IJERPH, MDPI, vol. 18(8), pages 1-13, April.
    • Handle: RePEc:gam:jijerp:v:18:y:2021:i:8:p:4008-:d:534000
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