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Mediterranean Diet Implementation to Protect against Advanced Lung Cancer Index (ALI) Rise: Study Design and Preliminary Results of a Randomised Controlled Trial

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  • Aristea Gioxari

    (Department of Dietetics and Nutritional Science, School of Health Science and Education, Harokopio University, 17671 Athens, Greece
    These authors contributed equally to this work.)

  • Dimitrios Tzanos

    (Department of Dietetics and Nutritional Science, School of Health Science and Education, Harokopio University, 17671 Athens, Greece
    These authors contributed equally to this work.)

  • Christina Kostara

    (Department of Nutrition, IASO Hospital, 15123 Athens, Greece)

  • Panos Papandreou

    (Department of Nutrition, IASO Hospital, 15123 Athens, Greece)

  • Giannis Mountzios

    (Department of Medical Oncology, Henry Dunant Hospital Center, 11526 Athens, Greece)

  • Maria Skouroliakou

    (Department of Dietetics and Nutritional Science, School of Health Science and Education, Harokopio University, 17671 Athens, Greece)

Abstract

The Mediterranean diet (MD) has been inversely associated with lung cancer (LC) risk. Hereby we show the preliminary results of our prospective randomised controlled trial in inflammatory and nutritional status of LC patients after 3-month implementation of MD. In total, 30 patients with small-cell or non-small-cell LC (stages III–IV) were enrolled. They were randomly assigned either to Control group, receiving general nutritional guidelines, or the MD group, in which a personalised MD plan was provided. Medical and dietary history, anthropometrics, blood biomarkers, and circulating antioxidant vitamins were assessed. The main outcome was a significantly higher advanced lung cancer inflammation index (ALI) in patients of the control arm than those following MD ( p = 0.003). In the MD group, platelets were significantly reduced at the study endpoint ( p = 0.044). BMI and body fat mass remained unchanged in both arms, but serum glucose was significantly higher in control compared to MD group ( p = 0.017). In conclusion, we showed for the first time that implementing a personalised MD for 3 months is promising to regulate prognostic biomarkers in advanced LC. The final results of our on-going trial will shed a light on the inflammatory, antioxidant and nutritional status of LC patients following MD.

Suggested Citation

  • Aristea Gioxari & Dimitrios Tzanos & Christina Kostara & Panos Papandreou & Giannis Mountzios & Maria Skouroliakou, 2021. "Mediterranean Diet Implementation to Protect against Advanced Lung Cancer Index (ALI) Rise: Study Design and Preliminary Results of a Randomised Controlled Trial," IJERPH, MDPI, vol. 18(7), pages 1-14, April.
    • Handle: RePEc:gam:jijerp:v:18:y:2021:i:7:p:3700-:d:528729
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    1. Erwin F. Wagner & Michele Petruzzelli, 2015. "A waste of insulin interference," Nature, Nature, vol. 521(7553), pages 430-431, May.
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