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Serum Levels of Fibroblast Growth Factor 21 Are Positively Associated with Aortic Stiffness in Patients with Type 2 Diabetes Mellitus

Author

Listed:
  • Sin-Yi Huang

    (Department of General Practice, Far Eastern Memorial Hospital, New Taipei City 22016, Taiwan
    These authors contributed equally to this work.)

  • Du-An Wu

    (School of Medicine, Tzu-Chi University, Hualien 970374, Taiwan
    Division of Metabolism and Endocrinology, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Hualien 970473, Taiwan
    These authors contributed equally to this work.)

  • Jen-Pi Tsai

    (School of Medicine, Tzu-Chi University, Hualien 970374, Taiwan
    Division of Nephrology, Department of Internal Medicine, Dalin Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Chiayi 62247, Taiwan)

  • Bang-Gee Hsu

    (School of Medicine, Tzu-Chi University, Hualien 970374, Taiwan
    Division of Nephrology, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Hualien 970473, Taiwan)

Abstract

Aortic stiffness (AS), assessed using carotid–femoral pulse wave velocity (cfPWV), is associated with cardiovascular disease in type 2 diabetes mellitus (T2DM). The relationship between serum fibroblast growth factor 21 (FGF-21) and AS in T2DM patients was evaluated. Fasting serum FGF-21 levels of 130 T2DM patients were measured using an enzyme immunoassay kit. A validated tonometry system was used to measure cfPWV (>10 m/s indicated AS). Of these T2DM patients, 34.6% were defined as the AS group. T2DM patients with AS were older; exhibited higher systolic blood pressure, diastolic blood pressure, and body fat mass; higher triglyceride, fasting glucose, glycosylated hemoglobin, and creatinine levels; higher urine albumin-to-creatinine ratios and serum FGF-21 levels; and lower estimated glomerular filtration rates. The FGF-21 level (odds ratio = 1.005, 95% confidence interval: 1.002–1.009, p = 0.002) as well as systolic blood pressure was an independent predictor of AS and positively correlated to cfPWV values (β = 0.369, p < 0.001) in T2DM patients. For T2DM patients, serum FGF-21 level could be a predictor for AS.

Suggested Citation

  • Sin-Yi Huang & Du-An Wu & Jen-Pi Tsai & Bang-Gee Hsu, 2021. "Serum Levels of Fibroblast Growth Factor 21 Are Positively Associated with Aortic Stiffness in Patients with Type 2 Diabetes Mellitus," IJERPH, MDPI, vol. 18(7), pages 1-9, March.
    • Handle: RePEc:gam:jijerp:v:18:y:2021:i:7:p:3434-:d:524436
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    References listed on IDEAS

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    1. Yin-Ting Wu & Bang-Gee Hsu & Chih-Hsien Wang & Yu-Li Lin & Yu-Hsien Lai & Chiu-Huang Kuo, 2020. "Lower Serum Fibroblast Growth Factor 21 Levels are Associated with Normal Lumbar Spine Bone Mineral Density in Hemodialysis Patients," IJERPH, MDPI, vol. 17(6), pages 1-8, March.
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