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Incidence of Pregnancy-Associated Cancer in Two Canadian Provinces: A Population-Based Study

Author

Listed:
  • Amy Metcalfe

    (Department of Obstetrics and Gynecology, University of Calgary, Calgary, AB T2N 1N4, Canada
    Department of Medicine, University of Calgary, Calgary, AB T2N 1N4, Canada
    Department of Community Health Sciences, University of Calgary, Calgary, AB T2N 1N4, Canada)

  • Zoe F. Cairncross

    (Department of Obstetrics and Gynecology, University of Calgary, Calgary, AB T2N 1N4, Canada)

  • Christine M. Friedenreich

    (Department of Community Health Sciences, University of Calgary, Calgary, AB T2N 1N4, Canada
    Department of Oncology, University of Calgary, Calgary, AB T2N 1N4, Canada
    Department of Cancer Epidemiology and Prevention Research, Cancer Care Alberta, Alberta Health Services, Calgary, AB T2S 3C3, Canada)

  • Joel G. Ray

    (Department of Medicine, University of Toronto, Toronto, ON M5S 1A1, Canada
    Department of Obstetrics and Gynecology, University of Toronto, Toronto, ON M5S 1A1, Canada
    SickKids Research Institute, Toronto, ON M5G 0A4, Canada)

  • Gregg Nelson

    (Department of Obstetrics and Gynecology, University of Calgary, Calgary, AB T2N 1N4, Canada)

  • Deshayne B. Fell

    (School of Epidemiology and Public Health, University of Ottawa, Ottawa, ON K1N 6N5, Canada
    Children’s Hospital of Eastern Ontario Research Institute, Ottawa, ON K1H 5B2, Canada)

  • Sarka Lisonkova

    (Department of Obstetrics and Gynecology, University of British Columbia, Vancouver, BC V6T 1Z4, Canada)

  • Parveen Bhatti

    (Cancer Control Research, BC Cancer, Vancouver, BC V5Z 1G1, Canada)

  • Carly McMorris

    (Werkland School of Education, University of Calgary, Calgary, AB T2N 1N4, Canada)

  • Khokan C. Sikdar

    (Department of Community Health Sciences, University of Calgary, Calgary, AB T2N 1N4, Canada
    Alberta Health Services, Calgary, AB T5J 3E4, Canada)

  • Lorraine Shack

    (Department of Community Health Sciences, University of Calgary, Calgary, AB T2N 1N4, Canada
    Department of Oncology, University of Calgary, Calgary, AB T2N 1N4, Canada
    Cancer Research and Analytics, Cancer Control Alberta, Alberta Health Services, Calgary, AB T5J 3E4, Canada)

Abstract

Pregnancy-associated cancer—that is diagnosed in pregnancy or within 365 days after delivery—is increasingly common as cancer therapy evolves and survivorship increases. This study assessed the incidence and temporal trends of pregnancy-associated cancer in Alberta and Ontario—together accounting for 50% of Canada’s entire population. Linked data from the two provincial cancer registries and health administrative data were used to ascertain new diagnoses of cancer, livebirths, stillbirths and induced abortions among women aged 18–50 years, from 2003 to 2015. The annual crude incidence rate (IR) was calculated as the number of women with a pregnancy-associated cancer per 100,000 deliveries. A nonparametric test for trend assessed for any temporal trends. In Alberta, the crude IR of pregnancy-associated cancer was 156.2 per 100,000 deliveries (95% CI 145.8–166.7), and in Ontario, the IR was 149.4 per 100,000 deliveries (95% CI 143.3–155.4). While no statistically significant temporal trend in the IR of pregnancy-associated cancer was seen in Alberta, there was a rise in Ontario ( p = 0.01). Pregnancy-associated cancer is common enough to warrant more detailed research on maternal, pregnancy and child outcomes, especially as cancer therapies continue to evolve.

Suggested Citation

  • Amy Metcalfe & Zoe F. Cairncross & Christine M. Friedenreich & Joel G. Ray & Gregg Nelson & Deshayne B. Fell & Sarka Lisonkova & Parveen Bhatti & Carly McMorris & Khokan C. Sikdar & Lorraine Shack, 2021. "Incidence of Pregnancy-Associated Cancer in Two Canadian Provinces: A Population-Based Study," IJERPH, MDPI, vol. 18(6), pages 1-7, March.
    • Handle: RePEc:gam:jijerp:v:18:y:2021:i:6:p:3100-:d:519077
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