IDEAS home Printed from https://ideas.repec.org/a/gam/jijerp/v18y2021i5p2322-d506872.html
   My bibliography  Save this article

Micro-Vesicles of Moringa oleifera Seeds in Heterozygous Rats for DAT Gene: Effects of Oral Intake on Behavioral Profile and Hematological Parameters

Author

Listed:
  • Clelia Buccheri

    (Center for Behavioral Sciences and Mental Health, Italian National Institute of Health, 00161 Rome, Italy
    Department of Biological Sciences, Tor Vergata University, 00133 Rome, Italy)

  • Fabiana Festucci

    (Center for Behavioral Sciences and Mental Health, Italian National Institute of Health, 00161 Rome, Italy
    Department of Biotechnological and Applied Clinical Sciences, University of L’Aquila, 67010 L’Aquila, Italy)

  • Marina Potestà

    (Department of Biological Sciences, Tor Vergata University, 00133 Rome, Italy)

  • Valentina Roglia

    (Department of Biological Sciences, Tor Vergata University, 00133 Rome, Italy)

  • Roberta Bernardini

    (Interdepartmental Centre of Comparative Medicine, Alternative Techniques and Aquaculture, Tor Vergata University, 00133 Rome, Italy)

  • Antonella Minutolo

    (Department of Biological Sciences, Tor Vergata University, 00133 Rome, Italy)

  • Carla Montesano

    (Department of Biological Sciences, Tor Vergata University, 00133 Rome, Italy)

  • Walter Adriani

    (Center for Behavioral Sciences and Mental Health, Italian National Institute of Health, 00161 Rome, Italy)

Abstract

Previous studies have shown multiple biological properties of Moringa oleifera , a plant native to Africa and Asia. In the present study, potential physiological properties of microvesicles extracted from Moringa oleifera seeds were assessed. For this purpose, we investigated behavioral profile and hematological parameters in a recent rat model characterized by dysregulation in dopamine transporter, a key regulator of dopaminergic system. Experimental design consisted of male Wistar-DAT rats aged between two and four months: wild-type (WT) ( n = 5) and heterozygous (DATHET) ( n = 4) control groups, which drank tap water; WT ( n = 5) and DATHET ( n = 6) groups which drank a solution of Moringa microvesicles and water (2: 68 mL per day), which was orally administered for two months. Rats were monitored for spontaneous locomotor activity on a 24/7 basis. In the early lit hours, treated DATHET subjects showed higher locomotor activity, proposing a sleep-delay effect of Moringa . In forced swimming test, WT subjects who took Moringa exhibited more depressive behavior. In DATHET rats, Moringa seemed to potentiate the struggle to find a way out, counteracting an initial panic. Hemoglobin and hematocrit underwent opposite changes in either genotype, supporting the opposite effects on behavioral phenotype observed. Future work is clearly needed to further explore these preliminary profiles.

Suggested Citation

  • Clelia Buccheri & Fabiana Festucci & Marina Potestà & Valentina Roglia & Roberta Bernardini & Antonella Minutolo & Carla Montesano & Walter Adriani, 2021. "Micro-Vesicles of Moringa oleifera Seeds in Heterozygous Rats for DAT Gene: Effects of Oral Intake on Behavioral Profile and Hematological Parameters," IJERPH, MDPI, vol. 18(5), pages 1-14, February.
    • Handle: RePEc:gam:jijerp:v:18:y:2021:i:5:p:2322-:d:506872
    as

    Download full text from publisher

    File URL: https://www.mdpi.com/1660-4601/18/5/2322/pdf
    Download Restriction: no
    File URL: https://www.mdpi.com/1660-4601/18/5/2322/
    Download Restriction: no
    ---><---

    References listed on IDEAS

    as
    1. Leonora Balaj & Ryan Lessard & Lixin Dai & Yoon-Jae Cho & Scott L. Pomeroy & Xandra O. Breakefield & Johan Skog, 2011. "Tumour microvesicles contain retrotransposon elements and amplified oncogene sequences," Nature Communications, Nature, vol. 2(1), pages 1-9, September.
    Full references (including those not matched with items on IDEAS)

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.

      Corrections

      All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:gam:jijerp:v:18:y:2021:i:5:p:2322-:d:506872. See general information about how to correct material in RePEc.

      If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

      If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

      If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

      For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: MDPI Indexing Manager (email available below). General contact details of provider: https://www.mdpi.com .

      Please note that corrections may take a couple of weeks to filter through the various RePEc services.

      IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.