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Plasma Xanthine Oxidoreductase Activity Is Associated with a High Risk of Cardiovascular Disease in a General Japanese Population

Author

Listed:
  • Yuka Kotozaki

    (Iwate Tohoku Medical Megabank Organization, Iwate Medical University, Yahaba 028-3694, Japan)

  • Mamoru Satoh

    (Iwate Tohoku Medical Megabank Organization, Iwate Medical University, Yahaba 028-3694, Japan
    Division of Biomedical Information Analysis, Institute for Biomedical Sciences, Iwate Medical University, Yahaba 028-3694, Japan)

  • Kozo Tanno

    (Iwate Tohoku Medical Megabank Organization, Iwate Medical University, Yahaba 028-3694, Japan
    Department of Hygiene and Preventive Medicine, Iwate Medical University, Yahaba 028-3694, Japan)

  • Hideki Ohmomo

    (Iwate Tohoku Medical Megabank Organization, Iwate Medical University, Yahaba 028-3694, Japan)

  • Ryo Otomo

    (Iwate Tohoku Medical Megabank Organization, Iwate Medical University, Yahaba 028-3694, Japan)

  • Fumitaka Tanaka

    (Iwate Tohoku Medical Megabank Organization, Iwate Medical University, Yahaba 028-3694, Japan
    Division of Nephrology and Hypertension, Department of Internal Medicine, Iwate Medical University, Yahaba 028-3694, Japan)

  • Takahito Nasu

    (Iwate Tohoku Medical Megabank Organization, Iwate Medical University, Yahaba 028-3694, Japan
    Division of Biomedical Information Analysis, Institute for Biomedical Sciences, Iwate Medical University, Yahaba 028-3694, Japan
    Division of Cardiology, Department of Internal Medicine, Iwate Medical University, Yahaba 028-3694, Japan)

  • Satoru Taguchi

    (Division of Cardiology, Department of Internal Medicine, Iwate Medical University, Yahaba 028-3694, Japan)

  • Hiroto Kikuchi

    (Division of Cardiology, Department of Internal Medicine, Iwate Medical University, Yahaba 028-3694, Japan)

  • Takamasa Kobayashi

    (Division of Cardiology, Department of Internal Medicine, Iwate Medical University, Yahaba 028-3694, Japan)

  • Atsushi Shimizu

    (Iwate Tohoku Medical Megabank Organization, Iwate Medical University, Yahaba 028-3694, Japan
    Division of Biomedical Information Analysis, Institute for Biomedical Sciences, Iwate Medical University, Yahaba 028-3694, Japan)

  • Kiyomi Sakata

    (Iwate Tohoku Medical Megabank Organization, Iwate Medical University, Yahaba 028-3694, Japan
    Department of Hygiene and Preventive Medicine, Iwate Medical University, Yahaba 028-3694, Japan)

  • Jiro Hitomi

    (Iwate Tohoku Medical Megabank Organization, Iwate Medical University, Yahaba 028-3694, Japan
    Department of Anatomy, Iwate Medical University, Yahaba 028-3694, Japan)

  • Kenji Sobue

    (Department of Neuroscience, Institute for Biomedical Sciences, Iwate Medical University, Yahaba 028-3694, Japan)

  • Makoto Sasaki

    (Iwate Tohoku Medical Megabank Organization, Iwate Medical University, Yahaba 028-3694, Japan
    Division of Ultrahigh field MRI, Institute for Biomedical Sciences, Iwate Medical University, Yahaba 028-3694, Japan)

Abstract

The purpose of this study was to investigate the association between xanthine oxidoreductase (XOR) activity and a high risk of cardiovascular disease (CVD) in a general Japanese population. The Iwate Tohoku Medical Megabank Organization pooled individual participant data from a general population-based cohort study in Iwate prefecture. The cardiovascular risk was calculated using the Framingham Risk Score (FRS). A total of 1605 of the 1631 participants (98.4%) had detectable XOR activity. Multiple regression analysis demonstrated that XOR activity was independently associated with body mass index (β = 0.26, p < 0.001), diabetes (β = 0.09, p < 0.001), dyslipidemia (β = 0.08, p = 0.001), and uric acid (β = 0.13, p < 0.001). Multivariate analysis showed that the highest quartile of XOR activity was associated with a high risk for CVD (FRS ≥ 15) after adjustment for baseline characteristics (OR 2.93, 95% CI 1.16–7.40). The area under the receiver operating characteristic curves of the FRS with XOR activity was 0.81 ( p = 0.008). XOR activity is associated with a high risk for CVD, suggesting that high XOR activity may indicate cardiovascular risk in a general Japanese population.

Suggested Citation

  • Yuka Kotozaki & Mamoru Satoh & Kozo Tanno & Hideki Ohmomo & Ryo Otomo & Fumitaka Tanaka & Takahito Nasu & Satoru Taguchi & Hiroto Kikuchi & Takamasa Kobayashi & Atsushi Shimizu & Kiyomi Sakata & Jiro , 2021. "Plasma Xanthine Oxidoreductase Activity Is Associated with a High Risk of Cardiovascular Disease in a General Japanese Population," IJERPH, MDPI, vol. 18(4), pages 1-10, February.
    • Handle: RePEc:gam:jijerp:v:18:y:2021:i:4:p:1894-:d:500140
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