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Urinary Bisphenol A, F and S Levels and Semen Quality in Young Adult Danish Men

Author

Listed:
  • Thea Emily Benson

    (Department of Public Health, Research Unit for Epidemiology, Aarhus University, 8000 Aarhus, Denmark)

  • Anne Gaml-Sørensen

    (Department of Public Health, Research Unit for Epidemiology, Aarhus University, 8000 Aarhus, Denmark)

  • Andreas Ernst

    (Department of Public Health, Research Unit for Epidemiology, Aarhus University, 8000 Aarhus, Denmark
    Department of Urology, Regional Hospital of West Jutland, 7500 Holstebro, Denmark)

  • Nis Brix

    (Department of Public Health, Research Unit for Epidemiology, Aarhus University, 8000 Aarhus, Denmark
    Department of Clinical Genetics, Aarhus University Hospital, 8200 Aarhus, Denmark)

  • Karin Sørig Hougaard

    (Department of Public Health, The Faculty of Health Sciences, University of Copenhagen, 1014 Copenhagen, Denmark
    National Research Centre for the Working Environment, 2100 Copenhagen, Denmark)

  • Katia Keglberg Hærvig

    (Department of Public Health, The Faculty of Health Sciences, University of Copenhagen, 1014 Copenhagen, Denmark
    Department of Occupational and Environmental Medicine, Bispebjerg and Frederiksberg Hospital, 2400 Copenhagen, Denmark)

  • Jens Peter Ellekilde Bonde

    (Department of Public Health, The Faculty of Health Sciences, University of Copenhagen, 1014 Copenhagen, Denmark
    Department of Occupational and Environmental Medicine, Bispebjerg and Frederiksberg Hospital, 2400 Copenhagen, Denmark)

  • Sandra Søgaard Tøttenborg

    (Department of Occupational and Environmental Medicine, Bispebjerg and Frederiksberg Hospital, 2400 Copenhagen, Denmark)

  • Christian H. Lindh

    (Division of Occupational and Environmental Medicine, Lund University, 22363 Lund, Sweden)

  • Cecilia Høst Ramlau-Hansen

    (Department of Public Health, Research Unit for Epidemiology, Aarhus University, 8000 Aarhus, Denmark)

  • Gunnar Toft

    (Department of Clinical Medicine, Department of Clinical Epidemiology, Aarhus University, 8200 Aarhus, Denmark
    Steno Diabetes Center, Aarhus University Hospital, 8200, Aarhus, Denmark)

Abstract

Bisphenol A (BPA) is considered an endocrine disruptor and has been associated with deleterious effects on spermatogenesis and male fertility. Bisphenol F (BPF) and S (BPS) are structurally similar to BPA, but knowledge of their effects on male fertility remains limited. In this cross–sectional study, we investigated the associations between exposure to BPA, BPF, and BPS and semen quality in 556 men 18–20 years of age from the Fetal Programming of Semen Quality (FEPOS) cohort. A urine sample was collected from each participant for determination of BPA, BPF, and BPS concentrations while a semen sample was collected to determine ejaculate volume, sperm concentration, total sperm count, sperm motility, and sperm morphology. Associations between urinary bisphenol levels (continuous and quartile–divided) and semen characteristics were estimated using a negative binomial regression model adjusting for urine creatinine concentration, alcohol intake, smoking status, body mass index (BMI), fever, sexual abstinence time, maternal pre–pregnancy BMI, and first trimester smoking, and highest parental education during first trimester. We found no associations between urinary bisphenol of semen quality in a sample of young men from the general Danish population.

Suggested Citation

  • Thea Emily Benson & Anne Gaml-Sørensen & Andreas Ernst & Nis Brix & Karin Sørig Hougaard & Katia Keglberg Hærvig & Jens Peter Ellekilde Bonde & Sandra Søgaard Tøttenborg & Christian H. Lindh & Cecilia, 2021. "Urinary Bisphenol A, F and S Levels and Semen Quality in Young Adult Danish Men," IJERPH, MDPI, vol. 18(4), pages 1-12, February.
    • Handle: RePEc:gam:jijerp:v:18:y:2021:i:4:p:1742-:d:497555
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    References listed on IDEAS

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    1. Lidia Caporossi & Alessandra Alteri & Giovanni Campo & Enrico Paci & Giovanna Tranfo & Silvia Capanna & Enrico Papaleo & Daniela Pigini & Paola Viganò & Bruno Papaleo, 2020. "Cross Sectional Study on Exposure to BPA and Phthalates and Semen Parameters in Men Attending a Fertility Center," IJERPH, MDPI, vol. 17(2), pages 1-18, January.
    2. Jonatan Axelsson & Lars Rylander & Anna Rignell-Hydbom & Karl Ågren Silfver & Amelie Stenqvist & Aleksander Giwercman, 2013. "The Impact of Paternal and Maternal Smoking on Semen Quality of Adolescent Men," PLOS ONE, Public Library of Science, vol. 8(6), pages 1-8, June.
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