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Prevalence of Undernutrition and Effect of Body Weight Loss on Survival among Pediatric Cancer Patients in Northeastern Hungary

Author

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  • Orsolya Kadenczki

    (Department of Pediatrics, University of Debrecen, 4032 Debrecen, Hungary)

  • Attila Csaba Nagy

    (Department of Preventive Medicine, Faculty of Public Health, University of Debrecen, 4032 Debrecen, Hungary)

  • Csongor Kiss

    (Department of Pediatrics, University of Debrecen, 4032 Debrecen, Hungary)

Abstract

Undernutrition is a prevalent condition in pediatric malignancy patients leading to unfavorable outcomes. The aim of this retrospective study was to determine the nutritional status and rate of undernutrition in 174 Hungarian pediatric patients with malignancies and the impact on 5-year survival based on anthropometric measurements. At the time of diagnosis, 5.0%, 4.6%, and 4.0% of patients were undernourished as determined by body weight (BW), weight-for-height (WFH), and body mass index (BMI) Z-score, respectively. The rate of undernutrition was 30.5% using ideal body weight percent (IBW%). Undernutrition at the time of diagnosis worsened the five-year overall survival only in solid tumor patients as defined by BMI Z-score and IBW%. Furthermore, 26.5% of patients became undernourished based on IBW% during the treatment period. Deterioration of nutritional status during treatment unfavorably influenced overall survival in both hematological and solid tumor subsets. Abnormal BW, WFH, and BMI Z-score were associated with poor prognosis in the hematologic group. The mortality risk was higher among hematologic patients with weight loss exceeding 20%. In conclusion, IBW% seems to be the most sensitive parameter to estimate undernutrition. Furthermore, BMI Z-score in both groups and severe weight loss in the hematological group may influence clinical outcome and play a role in prognosis assessment.

Suggested Citation

  • Orsolya Kadenczki & Attila Csaba Nagy & Csongor Kiss, 2021. "Prevalence of Undernutrition and Effect of Body Weight Loss on Survival among Pediatric Cancer Patients in Northeastern Hungary," IJERPH, MDPI, vol. 18(4), pages 1-11, February.
    • Handle: RePEc:gam:jijerp:v:18:y:2021:i:4:p:1478-:d:493473
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    References listed on IDEAS

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    1. Claudia Marotta & Francesco Di Gennaro & Damiano Pizzol & Geoffrey Madeira & Laura Monno & Annalisa Saracino & Giovanni Putoto & Alessandra Casuccio & Walter Mazzucco, 2018. "The At Risk Child Clinic (ARCC): 3 Years of Health Activities in Support of the Most Vulnerable Children in Beira, Mozambique," IJERPH, MDPI, vol. 15(7), pages 1-8, June.
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    Cited by:

    1. Orsolya Kadenczki & Antal Dezsofi & Aron Cseh & Daniel Szucs & Noemi Vass & Eva Nemes & Andras Tarnok & Erzsebet Szakos & Ildiko Guthy & Marta Kovacs & Anna Karoliny & Judit Czelecz & Csongor Kiss & K, 2022. "Disease Activity Is Associated with Obesity in Newly Diagnosed Pediatric Patients with Ulcerative Colitis," IJERPH, MDPI, vol. 19(23), pages 1-12, December.

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