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Toothpastes with Enzymes Support Gum Health and Reduce Plaque Formation

Author

Listed:
  • Pune N. Paqué

    (Clinic of Conservative and Preventive Dentistry, Center of Dental Medicine, University of Zurich, Plattenstrasse 11, 8032 Zurich, Switzerland)

  • Patrick R. Schmidlin

    (Clinic of Conservative and Preventive Dentistry, Center of Dental Medicine, University of Zurich, Plattenstrasse 11, 8032 Zurich, Switzerland)

  • Daniel B. Wiedemeier

    (Statistical Services, Center of Dental Medicine, University of Zurich, Plattenstrasse 11, 8032 Zurich, Switzerland)

  • Florian J. Wegehaupt

    (Clinic of Conservative and Preventive Dentistry, Center of Dental Medicine, University of Zurich, Plattenstrasse 11, 8032 Zurich, Switzerland)

  • Phoebe D. Burrer

    (Clinic of Conservative and Preventive Dentistry, Center of Dental Medicine, University of Zurich, Plattenstrasse 11, 8032 Zurich, Switzerland)

  • Philipp Körner

    (Clinic of Conservative and Preventive Dentistry, Center of Dental Medicine, University of Zurich, Plattenstrasse 11, 8032 Zurich, Switzerland)

  • Shengjile Deari

    (Clinic of Conservative and Preventive Dentistry, Center of Dental Medicine, University of Zurich, Plattenstrasse 11, 8032 Zurich, Switzerland)

  • Michel-Angelo Sciotti

    (School of Life Sciences, Institute for Chemistry and Bioanalytics, University of Applied Sciences Northern Switzerland, Hofackerstrasse 30, 4132 Muttenz, Switzerland)

  • Thomas Attin

    (Clinic of Conservative and Preventive Dentistry, Center of Dental Medicine, University of Zurich, Plattenstrasse 11, 8032 Zurich, Switzerland)

Abstract

Enzymes in toothpastes can support host immune responses, and thus maintain oral health. This study aimed to investigate gingival health and the plaque-reducing effects of enzyme-containing toothpastes. A laboratory study tested the antimicrobial potential of different enzyme-containing toothpaste formulations. Two promising formulations (enzyme-containing toothpastes with glucose oxidase and D-glucose with (C+) and without Citrox (C−) Citrox) were investigated in a clinical crossover trial (two slurries: sodium lauryl sulfate-containing (SLS), a toothpaste without SLS (reference), and water). Subjects ( n = 20) abstained from toothbrushing for four days and rinsed with a toothpaste slurry. Bleeding on probing (BOP) and plaque indices (PI) were measured. A mixed linear model was used to statistically compare the slurries with respect to BOP and PI change. The in vitro bacterial growth-inhibiting evaluation showed the best results for SLS, followed by C+ and C−. The change in BOP and PI exhibited statistically significant differences to water rinsing (BOP; PI changes in % points (difference of the baseline and post-rinse values: water = 8.8%; 90.0%; C+ = −1.4%; 80.4%; SLS = 1.5%; 72.1%; reference = 0.8%; 77.5%; C− = −1.8%; 75.1%). All slurries exhibited anti-gingivitis and anti-plaque effects, resulting in a prophylactic benefit for limited-access regions during brushing.

Suggested Citation

  • Pune N. Paqué & Patrick R. Schmidlin & Daniel B. Wiedemeier & Florian J. Wegehaupt & Phoebe D. Burrer & Philipp Körner & Shengjile Deari & Michel-Angelo Sciotti & Thomas Attin, 2021. "Toothpastes with Enzymes Support Gum Health and Reduce Plaque Formation," IJERPH, MDPI, vol. 18(2), pages 1-14, January.
  • Handle: RePEc:gam:jijerp:v:18:y:2021:i:2:p:835-:d:483225
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