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An Investigation of the Wild Rat Crown Incisor as an Indicator of Lead (Pb) Exposure Using Inductively Couple Plasma Mass Spectrometry (ICP-MS) and Laser Ablation ICP-MS

Author

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  • Andrew Kataba

    (Laboratory of Toxicology, Department of Environmental Veterinary Sciences, Faculty of Veterinary Medicine, Hokkaido University, Kita 18 Nishi 9, Kita-ku, Sapporo 060-0818, Japan
    School of Veterinary Medicine, The University of Zambia, P.O. Box 32379, Lusaka 10101, Zambia)

  • Shouta M. M. Nakayama

    (Laboratory of Toxicology, Department of Environmental Veterinary Sciences, Faculty of Veterinary Medicine, Hokkaido University, Kita 18 Nishi 9, Kita-ku, Sapporo 060-0818, Japan)

  • Hokuto Nakata

    (Laboratory of Toxicology, Department of Environmental Veterinary Sciences, Faculty of Veterinary Medicine, Hokkaido University, Kita 18 Nishi 9, Kita-ku, Sapporo 060-0818, Japan)

  • Haruya Toyomaki

    (Laboratory of Toxicology, Department of Environmental Veterinary Sciences, Faculty of Veterinary Medicine, Hokkaido University, Kita 18 Nishi 9, Kita-ku, Sapporo 060-0818, Japan)

  • Yared B. Yohannes

    (Laboratory of Toxicology, Department of Environmental Veterinary Sciences, Faculty of Veterinary Medicine, Hokkaido University, Kita 18 Nishi 9, Kita-ku, Sapporo 060-0818, Japan
    Department of Chemistry, College of Natural and Computational Science, University of Gondar, P.O. Box 196, Gondar 6200, Ethiopia)

  • John Yabe

    (School of Veterinary Medicine, The University of Zambia, P.O. Box 32379, Lusaka 10101, Zambia)

  • Kaampwe Muzandu

    (School of Veterinary Medicine, The University of Zambia, P.O. Box 32379, Lusaka 10101, Zambia)

  • Golden Zyambo

    (School of Veterinary Medicine, The University of Zambia, P.O. Box 32379, Lusaka 10101, Zambia)

  • Ayano Kubota

    (Department of Epidemiology and Environmental Health, Faculty of Medicine, Juntendo University, 2-1-1 Hongo, Bunkyo-ku, Tokyo 113-8421, Japan)

  • Takehisa Matsukawa

    (Department of Epidemiology and Environmental Health, Faculty of Medicine, Juntendo University, 2-1-1 Hongo, Bunkyo-ku, Tokyo 113-8421, Japan)

  • Kazuhito Yokoyama

    (Department of Epidemiology and Environmental Health, Faculty of Medicine, Juntendo University, 2-1-1 Hongo, Bunkyo-ku, Tokyo 113-8421, Japan)

  • Yoshinori Ikenaka

    (Laboratory of Toxicology, Department of Environmental Veterinary Sciences, Faculty of Veterinary Medicine, Hokkaido University, Kita 18 Nishi 9, Kita-ku, Sapporo 060-0818, Japan
    Water Research Group, School of Environmental Sciences and Development, North-West University, Private Bag X6001, Potchefstroom 2531, South Africa)

  • Mayumi Ishizuka

    (Laboratory of Toxicology, Department of Environmental Veterinary Sciences, Faculty of Veterinary Medicine, Hokkaido University, Kita 18 Nishi 9, Kita-ku, Sapporo 060-0818, Japan)

Abstract

Lead (Pb) is a metal toxicant of great public health concern. The present study investigated the applicability of the rat incisor in Pb exposure screening. The levels of lead in teeth (Pb-T) in the crown and root of incisors in laboratory Pb-exposed Sprague Dawley rats were quantified using inductively coupled plasma mass spectrometry (ICP-MS). The crown accumulated much Pb-T than the root of the Sprague Dawley rat incisor. The levels of lead in blood (Pb-B) were positively correlated with the Pb-T in the crown and root incisors of the Sprague Dawley rats. As an application of the Pb-T crown results in experimental rats, we subsequently analyzed the Pb-T in the crown incisors of Pb-exposed wild rats ( Rattus rattus ) sampled from residential sites within varying distances from an abandoned lead–zinc mine. The Pb-T accumulation in the crown of incisors of R. rattus rats decreased with increased distance away from the Pb–Zn mine. Furthermore, the Pb-T was strongly correlated ( r = 0.85) with the Pb levels in the blood. Laser ablation ICP-MS Pb-T mappings revealed a homogenous distribution of Pb in the incisor with an increased intensity of Pb-T localized in the tip of the incisor crown bearing an enamel surface in both Sprague Dawley and R. rattus rats. These findings suggest that Pb-T in the crown incisor may be reflective of the rat’s environmental habitat, thus a possible indicator of Pb exposure.

Suggested Citation

  • Andrew Kataba & Shouta M. M. Nakayama & Hokuto Nakata & Haruya Toyomaki & Yared B. Yohannes & John Yabe & Kaampwe Muzandu & Golden Zyambo & Ayano Kubota & Takehisa Matsukawa & Kazuhito Yokoyama & Yosh, 2021. "An Investigation of the Wild Rat Crown Incisor as an Indicator of Lead (Pb) Exposure Using Inductively Couple Plasma Mass Spectrometry (ICP-MS) and Laser Ablation ICP-MS," IJERPH, MDPI, vol. 18(2), pages 1-15, January.
    • Handle: RePEc:gam:jijerp:v:18:y:2021:i:2:p:767-:d:482124
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    References listed on IDEAS

    as
    1. Hokuto Nakata & Shouta M. M. Nakayama & Balazs Oroszlany & Yoshinori Ikenaka & Hazuki Mizukawa & Kazuyuki Tanaka & Tsunehito Harunari & Tsutomu Tanikawa & Wageh Sobhy Darwish & Yared B. Yohannes & Aks, 2017. "Monitoring Lead (Pb) Pollution and Identifying Pb Pollution Sources in Japan Using Stable Pb Isotope Analysis with Kidneys of Wild Rats," IJERPH, MDPI, vol. 14(1), pages 1-13, January.
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    Cited by:

    1. Hokuto Nakata & Akifumi Eguchi & Shouta M. M. Nakayama & John Yabe & Kaampwe Muzandu & Yoshinori Ikenaka & Chisato Mori & Mayumi Ishizuka, 2022. "Metabolomic Alteration in the Plasma of Wild Rodents Environmentally Exposed to Lead: A Preliminary Study," IJERPH, MDPI, vol. 19(1), pages 1-14, January.
    2. Golden Zyambo & John Yabe & Kaampwe Muzandu & Ethel M’kandawire & Kennedy Choongo & Andrew Kataba & Kenneth Chawinga & Allan Liazambi & Shouta M. M Nakayama & Hokuto Nakata & Mayumi Ishizuka, 2022. "Human Health Risk Assessment from Lead Exposure through Consumption of Raw Cow Milk from Free-Range Cattle Reared in the Vicinity of a Lead–Zinc Mine in Kabwe," IJERPH, MDPI, vol. 19(8), pages 1-16, April.

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