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Threshold for Relationship between Vitamin D and Parathyroid Hormone in Chinese Women of Childbearing Age

Author

Listed:
  • Yichun Hu

    (Key Laboratory of Trace Element Nutrition of National Health Committee, National Institute for Nutrition and Health, China CDC, Beijing 100050, China
    These authors contributed equally to this article.)

  • Siran Li

    (Key Laboratory of Trace Element Nutrition of National Health Committee, National Institute for Nutrition and Health, China CDC, Beijing 100050, China
    These authors contributed equally to this article.)

  • Jun Wang

    (Physical and Chemical Laboratory, Shenzhen Center for Chronic Disease Control, Shenzhen 518020, China)

  • Deqiang Zheng

    (Department of Epidemiology and Biostatistics, School of Public Health, Capital Medical University, Beijing 100069, China)

  • Huidi Zhang

    (Key Laboratory of Trace Element Nutrition of National Health Committee, National Institute for Nutrition and Health, China CDC, Beijing 100050, China)

  • Wei Yu

    (Physical and Chemical Laboratory, Shenzhen Center for Chronic Disease Control, Shenzhen 518020, China)

  • Lijia Zhu

    (Physical and Chemical Laboratory, Shenzhen Center for Chronic Disease Control, Shenzhen 518020, China)

  • Zhen Liu

    (Key Laboratory of Trace Element Nutrition of National Health Committee, National Institute for Nutrition and Health, China CDC, Beijing 100050, China)

  • Xiaoguang Yang

    (Key Laboratory of Trace Element Nutrition of National Health Committee, National Institute for Nutrition and Health, China CDC, Beijing 100050, China)

  • Lichen Yang

    (Key Laboratory of Trace Element Nutrition of National Health Committee, National Institute for Nutrition and Health, China CDC, Beijing 100050, China)

Abstract

Background : The aim of this study was to assess the relationship between serum 25-hydroxyvitamin D [25(OH)D] and serum intact parathyroid hormone (PTH) in Chinese childbearing women, and to estimate the optimum threshold of 25(OH)D that maximally inhibits the PTH, which is considered to be the optimal status for vitamin D sufficiency. Methods : Serum samples were selected from the biological samples’ bank of the Chinese Chronic Diseases and Nutrition Survey (CCDNS) 2015. The serum 25(OH)D concentration was determined by liquid chromatography tandem mass spectrometry and the serum PTH was determined by electronic chemiluminescence. Simple linear and partial correlation analysis, locally weighted regression smooth scatterplot (LOESS), nonlinear least squares estimation (NLS), and segmented regression (SR) were utilized to estimate the relationship of 25(OH)D and PTH, and to determine the threshold of 25(OH)D. Results: A total of 1568 serum samples of 25(OH)D concentration and PTH concentration were analyzed. A significant inverse relationship between 25(OH)D and PTH concentration was observed below 15.25 (14.22–16.28) ng/mL, and PTH decreased slowly with the increase of 25(OH)D above 16.75 (15.43–18.06) ng/mL after adjusting by age, latitude, city type, season, corrected calcium, and phosphorus. A very short plateau of PTH was found at 15.25 ng/mL and 16.75 ng/mL in terms of 25(OH)D according to LOESS, NLS, and SR. Conclusions : The serum 25(OH)D was negatively correlated with the serum PTH. The threshold of VitD sufficiency was found in the range of 14.22–18.06 ng/mL in terms of serum 25(OH)D concentration for Chinese childbearing women aged 18–44 years old.

Suggested Citation

  • Yichun Hu & Siran Li & Jun Wang & Deqiang Zheng & Huidi Zhang & Wei Yu & Lijia Zhu & Zhen Liu & Xiaoguang Yang & Lichen Yang, 2021. "Threshold for Relationship between Vitamin D and Parathyroid Hormone in Chinese Women of Childbearing Age," IJERPH, MDPI, vol. 18(24), pages 1-10, December.
    • Handle: RePEc:gam:jijerp:v:18:y:2021:i:24:p:13060-:d:699845
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