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Sudden Unexpected Death Caused by Cardiac Metastasization from Histiocytic Sarcoma

Author

Listed:
  • Alessandro Feola

    (Department of Experimental Medicine, University of Campania “Luigi Vanvitelli”, 80138 Naples, Italy)

  • Paola Ciamarra

    (Department of Experimental Medicine, University of Campania “Luigi Vanvitelli”, 80138 Naples, Italy)

  • Mariavictoria De Simone

    (Department of Experimental Medicine, University of Campania “Luigi Vanvitelli”, 80138 Naples, Italy)

  • Anna Carfora

    (Department of Experimental Medicine, University of Campania “Luigi Vanvitelli”, 80138 Naples, Italy)

  • Gelsomina Mansueto

    (Department of Advanced Medical and Surgical Sciences (DAMSS), University of Campania “Luigi Vanvitelli”, 80138 Naples, Italy
    Clinical Department of Laboratory Services, Public Health-Legal Medicine Unit, University of Campania Luigi Vanvitelli, Via Luciano Armanni 5, 80138 Naples, Italy
    Equally contributed.)

  • Carlo Pietro Campobasso

    (Department of Experimental Medicine, University of Campania “Luigi Vanvitelli”, 80138 Naples, Italy
    Equally contributed.)

Abstract

Background: Haematological malignancies, such as lymphoma and leukaemia, can have a variety of clinical manifestations. The most frequent cause of death from haematological malignancies is multiple organ failure due to neoplastic organ infiltration and/or septic shock. Histiocytic sarcoma (HS) is a rare malignant nodal or extranodal tumour with histiocytic immunophenotype that originates from a lymphohematopoietic precursor. The patients with HS usually have a poor prognosis due to its aggressive clinical behaviour. Rare cases of undiagnosed sudden HS death have been described in the literature. Methods: A forensic autopsy of a 46-year-old white male who died at home suddenly and unexpectedly without warning conditions or known diseases. Gross analysis, histology and toxicology were also performed. Results: The diagnosis of HS of the ileum with secondary nodal and cardiac metastatization was made. Conclusions: A prompt diagnosis of HS in life is paramount because it can make a difference in prognostic outcomes.

Suggested Citation

  • Alessandro Feola & Paola Ciamarra & Mariavictoria De Simone & Anna Carfora & Gelsomina Mansueto & Carlo Pietro Campobasso, 2021. "Sudden Unexpected Death Caused by Cardiac Metastasization from Histiocytic Sarcoma," IJERPH, MDPI, vol. 18(24), pages 1-6, December.
  • Handle: RePEc:gam:jijerp:v:18:y:2021:i:24:p:12911-:d:697070
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