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Occupational Exposure to Ultrafine Particles and Placental Histopathological Lesions: A Retrospective Study about 130 Cases

Author

Listed:
  • Anaïs Pasquiou

    (Department of Pathology, Bordeaux University Hospital, 33076 Bordeaux, France)

  • Fanny Pelluard

    (Department of Pathology, Bordeaux University Hospital, 33076 Bordeaux, France
    BaRITOn, INSERM U1053, University of Bordeaux, 33076 Bordeaux, France)

  • Guyguy Manangama

    (ARTEMIS Center, Bordeaux University Hospital, 33076 Bordeaux, France
    Bordeaux Population Health Research Center, Inserm UMR1219-EPICENE, University of Bordeaux, 33076 Bordeaux, France)

  • Patrick Brochard

    (ARTEMIS Center, Bordeaux University Hospital, 33076 Bordeaux, France
    Bordeaux Population Health Research Center, Inserm UMR1219-EPICENE, University of Bordeaux, 33076 Bordeaux, France)

  • Sabyne Audignon

    (ARTEMIS Center, Bordeaux University Hospital, 33076 Bordeaux, France
    Bordeaux Population Health Research Center, Inserm UMR1219-EPICENE, University of Bordeaux, 33076 Bordeaux, France)

  • Loïc Sentilhes

    (Department of Obstetrics and Gynecology, Bordeaux University Hospital, 33076 Bordeaux, France)

  • Fleur Delva

    (ARTEMIS Center, Bordeaux University Hospital, 33076 Bordeaux, France
    Bordeaux Population Health Research Center, Inserm UMR1219-EPICENE, University of Bordeaux, 33076 Bordeaux, France)

Abstract

Ultrafine particles (UFPs) are particles smaller than 100 nanometers that are produced unintentionally during human activities or natural phenomena. They have a higher biological reactivity than bigger particles and can reach the placenta after maternal exposure. One study has shown an association between maternal occupational exposure to UFPs and fetal growth restriction. Yet few studies have focused on the effects of UFP exposure on placental histopathological lesions. The aim of this study was to investigate the association between maternal occupational exposure to UFPs and histopathological lesions of their placenta. The analyses were based on data from the ARTEMIS Center. A job-exposure matrix was used to assess occupational exposure to UFPs. The histopathological placental exam was performed by two pathologists who were blinded to the exposure of each subject. The examination was conducted in accordance with the recommendations of the Amsterdam consensus. The study sample included 130 placentas (30 exposed, 100 unexposed). Maternal occupational exposure to UFPs during pregnancy is significantly associated with placental hypoplasia (the phenomenon affected 61% of the exposed patients and 34% of the unexposed ones, p < 0.01). Further research is needed to explain its pathophysiological mechanisms.

Suggested Citation

  • Anaïs Pasquiou & Fanny Pelluard & Guyguy Manangama & Patrick Brochard & Sabyne Audignon & Loïc Sentilhes & Fleur Delva, 2021. "Occupational Exposure to Ultrafine Particles and Placental Histopathological Lesions: A Retrospective Study about 130 Cases," IJERPH, MDPI, vol. 18(23), pages 1-12, December.
    • Handle: RePEc:gam:jijerp:v:18:y:2021:i:23:p:12719-:d:693558
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    References listed on IDEAS

    as
    1. Fleur Delva & Guyguy Manangama & Patrick Brochard & Raphaëlle Teysseire & Loïc Sentilhes, 2020. "The ARTEMIS Center: An Environmental Health Prevention Platform Dedicated to Reproduction," IJERPH, MDPI, vol. 17(3), pages 1-13, January.
    2. Linda C. Abbott & Andrew D. Maynard, 2010. "Exposure Assessment Approaches for Engineered Nanomaterials," Risk Analysis, John Wiley & Sons, vol. 30(11), pages 1634-1644, November.
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