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Regulatory Framework Implementation for the Prescription of Zolpidem in France, What Impact in the Older People?

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  • Alexandra Jobert

    (Nantes Université, Univ. Tours, INSERM, MethodS in Patients-Centered Outcomes and HEalth Research, SPHERE, F-44000 Nantes, France
    CHU Nantes, Research and Innovation Department, 5 allée de l’île gloriette, CEDEX, 44093 Nantes, France
    Alexandra Jobert and Marion Istvan are both first co-authors.)

  • Marion Istvan

    (Nantes Université, Univ. Tours, INSERM, MethodS in Patients-Centered Outcomes and HEalth Research, SPHERE, F-44000 Nantes, France
    CHU Nantes, Centre for Evaluation and Information on Pharmacodependence, Clinical Pharmacology Department, CEDEX, 44093 Nantes, France
    Alexandra Jobert and Marion Istvan are both first co-authors.)

  • Edouard-Jules Laforgue

    (Nantes Université, Univ. Tours, INSERM, MethodS in Patients-Centered Outcomes and HEalth Research, SPHERE, F-44000 Nantes, France
    CHU Nantes, Centre for Evaluation and Information on Pharmacodependence, Clinical Pharmacology Department, CEDEX, 44093 Nantes, France
    CHU Nantes, Addictology and Liaison-Psychiatry Department, CEDEX, 44093 Nantes, France)

  • Benoit Schreck

    (Nantes Université, Univ. Tours, INSERM, MethodS in Patients-Centered Outcomes and HEalth Research, SPHERE, F-44000 Nantes, France
    CHU Nantes, Addictology and Liaison-Psychiatry Department, CEDEX, 44093 Nantes, France)

  • Caroline Victorri-Vigneau

    (Nantes Université, Univ. Tours, INSERM, MethodS in Patients-Centered Outcomes and HEalth Research, SPHERE, F-44000 Nantes, France
    CHU Nantes, Centre for Evaluation and Information on Pharmacodependence, Clinical Pharmacology Department, CEDEX, 44093 Nantes, France)

Abstract

Background: Zolpidem is one of the most prescribed hypnotic drugs. In 2001, the World Health Organization alerted a risk of pharmacodependence associated with zolpidem. The French health authority decided in 2017 to enforce security on the prescription of zolpidem to reduce those risks. The aim of our study was to evaluate the impact of regulatory framework implementation, secure prescription pad, on the prevalence and incidence of prescriptions of zolpidem according to the age. Methods: This study was based on an observational study using the French healthcare data system. Two age categories were defined: “younger” and “older” (<65 years, ≥65 years); in order to study the evolution of prevalence and incidence of zolpidem use in our two groups, two periods were defined, before and after the implementation of the measure. Results: The prevalence decreased in the younger population by 51% (4012 vs. 7948 consumers), while that of the older population decreased by 42% (4151 vs. 7282). This difference in our two groups, with a greater decrease in the younger people, is statistically significant compared to the older people. Conclusion: Our study showed that regulatory framework implementation and mandatory secure prescription pad is more effective for decreasing prevalence of zolpidem prescription for younger people compared to older people.

Suggested Citation

  • Alexandra Jobert & Marion Istvan & Edouard-Jules Laforgue & Benoit Schreck & Caroline Victorri-Vigneau, 2021. "Regulatory Framework Implementation for the Prescription of Zolpidem in France, What Impact in the Older People?," IJERPH, MDPI, vol. 18(22), pages 1-10, November.
    • Handle: RePEc:gam:jijerp:v:18:y:2021:i:22:p:12099-:d:681797
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    Cited by:

    1. Edouard-Jules Laforgue & Morgane Rousselet & Antoine Claudon & Aurélie Aquizerate & Pascale Jolliet & Marion Istvan & Caroline Victorri-Vigneau, 2022. "Did the New French Regulation of Zolpidem Decrease the Problematic Consumption of Zolpidem? A Field Study among Users," IJERPH, MDPI, vol. 19(15), pages 1-12, July.

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