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Increased Prevalence of Atopic Dermatitis in Children Aged 0–3 Years Highly Exposed to Parabens

Author

Listed:
  • Johichi Arafune

    (Department of Environmental and Preventive Medicine, Kanazawa University Graduate School of Medical Sciences, 13-1 Takara-machi, Kanazawa 920-8640, Ishikawa, Japan)

  • Hiromasa Tsujiguchi

    (Department of Environmental and Preventive Medicine, Kanazawa University Graduate School of Medical Sciences, 13-1 Takara-machi, Kanazawa 920-8640, Ishikawa, Japan
    Advanced Preventive Medical Center, Kanazawa University, 13-1 Takara-machi, Kanazawa 920-8640, Ishikawa, Japan)

  • Akinori Hara

    (Department of Environmental and Preventive Medicine, Kanazawa University Graduate School of Medical Sciences, 13-1 Takara-machi, Kanazawa 920-8640, Ishikawa, Japan
    Advanced Preventive Medical Center, Kanazawa University, 13-1 Takara-machi, Kanazawa 920-8640, Ishikawa, Japan)

  • Yukari Shimizu

    (Department of Nursing, Faculty of Health Sciences, Komatsu University, 14-1 Mukaimotorimachi, Komatsu 923-0961, Ishikawa, Japan)

  • Daisuke Hori

    (Faculty of Medicine, University of Tsukuba, 1-1-1 Tennodai, Tsukuba 305-8575, Ibaraki, Japan)

  • Thao Thi Thu Nguyen

    (Faculty of Public Health, Haiphong University of Medicine and Pharmacy, Hai Phong 180000, Ngo Quyen, Vietnam)

  • Fumihiko Suzuki

    (Department of Environmental and Preventive Medicine, Kanazawa University Graduate School of Medical Sciences, 13-1 Takara-machi, Kanazawa 920-8640, Ishikawa, Japan)

  • Toshio Hamagishi

    (Department of Environmental and Preventive Medicine, Kanazawa University Graduate School of Medical Sciences, 13-1 Takara-machi, Kanazawa 920-8640, Ishikawa, Japan)

  • Yohei Yamada

    (Department of Environmental and Preventive Medicine, Kanazawa University Graduate School of Medical Sciences, 13-1 Takara-machi, Kanazawa 920-8640, Ishikawa, Japan)

  • Haruki Nakamura

    (Department of Environmental and Preventive Medicine, Kanazawa University Graduate School of Medical Sciences, 13-1 Takara-machi, Kanazawa 920-8640, Ishikawa, Japan)

  • Takahiro Yoshikawa

    (Department of Environmental and Preventive Medicine, Kanazawa University Graduate School of Medical Sciences, 13-1 Takara-machi, Kanazawa 920-8640, Ishikawa, Japan)

  • Koichiro Hayashi

    (Department of Environmental and Preventive Medicine, Kanazawa University Graduate School of Medical Sciences, 13-1 Takara-machi, Kanazawa 920-8640, Ishikawa, Japan)

  • Aki Shibata

    (Department of Environmental and Preventive Medicine, Kanazawa University Graduate School of Medical Sciences, 13-1 Takara-machi, Kanazawa 920-8640, Ishikawa, Japan)

  • Yuma Fukutomi

    (Clinical Research Center for Allergy and Rheumatology, National Hospital Organization Sagamihara National Hospital, 18-1 Sakuradai, Minami-ku, Sagamihara 252-0392, Kanagawa, Japan)

  • Yukihiro Ohya

    (Allergy Center, National Center for Child Health and Development, 2-10-1 Okura, Setagaya-ku, Tokyo 157-8535, Japan)

  • Kiwako Yamamoto-Hanada

    (Allergy Center, National Center for Child Health and Development, 2-10-1 Okura, Setagaya-ku, Tokyo 157-8535, Japan)

  • Go Muto

    (Department of Hygiene, Kitasato University School of Medicine, 1-15-1 Kitasato, Minami-ku, Sagamihara 252-0374, Kanagawa, Japan
    Center for Preventive Medical Science, Chiba University, 1-8-1, Inohana, Chuo-ku, Chiba 260-8670, Japan)

  • Ryoji Hirota

    (The Graduate School of Health Science, Matsumoto University, 2095-1 Niimura, Matsumoto 390-1295, Nagano, Japan)

  • Tadashi Konoshita

    (Third Department of Internal Medicine, University of Fukui Faculty of Medical Sciences, 23-3 Mat-suoka- Shimoaizaki, Eiheiji 910-1193, Fukui, Japan)

  • Yasuhiro Kambayashi

    (Department of Environmental and Preventive Medicine, Kanazawa University Graduate School of Medical Sciences, 13-1 Takara-machi, Kanazawa 920-8640, Ishikawa, Japan
    Department of Public Health, Faculty of Veterinary Medicine, Okayama University of Science, 1-3 Ikoinooka, Imabari 794-8555, Ehime, Japan)

  • Hiroyuki Nakamura

    (Department of Environmental and Preventive Medicine, Kanazawa University Graduate School of Medical Sciences, 13-1 Takara-machi, Kanazawa 920-8640, Ishikawa, Japan
    Advanced Preventive Medical Center, Kanazawa University, 13-1 Takara-machi, Kanazawa 920-8640, Ishikawa, Japan)

Abstract

The prevalence of allergic diseases, such as bronchial asthma, atopic dermatitis, nasal allergies (pollinosis), and food allergies, has been increasing in many countries. The hygiene hypothesis was recently considered from the perspective of exposure to antimicrobial agents and preservatives, such as parabens (CAS number, 94-13-3). It currently remains unclear whether parabens, which are included in many daily consumer products such as cosmetics, shampoos, and personal care products as preservative antimicrobial agents, induce or aggravate allergies. Therefore, the aim of the present study was to examine the relationship between exposure to parabens and the prevalence of allergic diseases in Japanese children. The cross-sectional epidemiology of 236 children aged 0–3 years who underwent health examinations in Shika town in Japan assessed individual exposure to parabens using urinary concentrations of parabens. The results obtained showed that the prevalence of atopic dermatitis was significantly higher in children with high urinary concentrations of parabens than in those with low concentrations ( p < 0.001). This relationship remained significant after adjustments for confounding factors, such as age, sex, Kaup’s index, and passive smoking ( p < 0.001). In conclusion, the present results from a population study suggested a relationship between atopic dermatitis and exposure to parabens. A longitudinal study using a larger sample number and a detailed examination of atopic dermatitis, including EASI scores and exposure to parabens, will be necessary.

Suggested Citation

  • Johichi Arafune & Hiromasa Tsujiguchi & Akinori Hara & Yukari Shimizu & Daisuke Hori & Thao Thi Thu Nguyen & Fumihiko Suzuki & Toshio Hamagishi & Yohei Yamada & Haruki Nakamura & Takahiro Yoshikawa & , 2021. "Increased Prevalence of Atopic Dermatitis in Children Aged 0–3 Years Highly Exposed to Parabens," IJERPH, MDPI, vol. 18(21), pages 1-10, November.
    • Handle: RePEc:gam:jijerp:v:18:y:2021:i:21:p:11657-:d:673468
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