IDEAS home Printed from https://ideas.repec.org/a/gam/jijerp/v18y2021i21p11362-d667604.html
   My bibliography  Save this article

CD34 and CD105 Microvessels in Resected Bone Specimen May Implicate Wound Healing in MRONJ

Author

Listed:
  • Antonia Marcianò

    (Department of Clinical and Experimental Medicine, University of Messina, 98124 Messina, Italy
    These authors contributed equally to the work.)

  • Antonio Ieni

    (Department of Human Pathology of Adults and Developmental Age, Gaetano Barresi, University of Messina, 98124 Messina, Italy
    These authors contributed equally to the work.)

  • Rodolfo Mauceri

    (Department of Surgical, Oncological, and Oral Sciences, University of Palermo, 90127 Palermo, Italy
    Department of Biomedical, Postgraduate School of Oral Surgery, Dental Sciences and Morphofunctional Imaging, University of Messina, 98124 Messina, Italy)

  • Giacomo Oteri

    (Department of Biomedical, Postgraduate School of Oral Surgery, Dental Sciences and Morphofunctional Imaging, University of Messina, 98124 Messina, Italy)

Abstract

Clinical treatment outcome of MRONJ (medication-related osteonecrosis of the jaw) surgery despite radical osseous removal and primary closure healing still shows differences in terms of outcome and disease recurrence. The study aims to assess the rate of angiogenesis of MRONJ lesions in order to understand the impact of angiogenesis and neoangiogenesis status on MRONJ surgical treatment outcome. This is the first study correlating microvessel density with prognosis in MRONJ surgically-treated patients. The immunohistochemical expression of CD34 and CD105 in MRONJ specimens obtained from surgically-treated patients was evaluated. The most vascularized areas detected by CD34 and CD105 were selected and the microvessel density value of the samples was registered. Samples were retrospectively divided according to the clinical outcome of MRONJ surgical treatment, dividing patients into two groups, “healed” and “not healed”. Statistical analysis was performed to assess if neovessels could influence treatment outcome in patients undergoing radical surgery. In the examined cohort, this value was highly predictive of better treatment outcome after radical surgery of MRONJ. Understanding of angiogenesis-dependent factors deserves further attention as a future target for MRONJ prevention and therapies.

Suggested Citation

  • Antonia Marcianò & Antonio Ieni & Rodolfo Mauceri & Giacomo Oteri, 2021. "CD34 and CD105 Microvessels in Resected Bone Specimen May Implicate Wound Healing in MRONJ," IJERPH, MDPI, vol. 18(21), pages 1-16, October.
    • Handle: RePEc:gam:jijerp:v:18:y:2021:i:21:p:11362-:d:667604
    as

    Download full text from publisher

    File URL: https://www.mdpi.com/1660-4601/18/21/11362/pdf
    Download Restriction: no
    File URL: https://www.mdpi.com/1660-4601/18/21/11362/
    Download Restriction: no
    ---><---

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:gam:jijerp:v:18:y:2021:i:21:p:11362-:d:667604. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: MDPI Indexing Manager (email available below). General contact details of provider: https://www.mdpi.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.