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Alcohol Drinking Pattern and Risk of Head and Neck Cancer: A Nationwide Cohort Study

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  • Hye Yeon Koo

    (Health Promotion Center, CHA Bundang Medical Center, Seongnam 13496, Korea
    Contributed equally as first authors.)

  • Kyungdo Han

    (Department of Statistics and Actuarial Science, Soongsil University, Seoul 06978, Korea
    Contributed equally as first authors.)

  • Dong Wook Shin

    (Department of Family Medicine/Supportive Care Center, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul 06351, Korea
    Department of Digital Health, SAIHST, Sungkyunkwan University, Seoul 06355, Korea
    Center for Clinical Epidemiology, SAIHST, Sungkyunkwan University, Seoul 06355, Korea)

  • Jung Eun Yoo

    (Department of Family Medicine, Healthcare System Gangnam Center, Seoul National University Hospital, Seoul 06236, Korea)

  • Mi Hee Cho

    (Samsung C&T Medical Clinic, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul 05288, Korea)

  • Keun Hye Jeon

    (Department of Family Medicine, CHA Gumi Medical Center, CHA University, Gumi 39295, Korea)

  • Dahye Kim

    (Department of Medical Statistics, The Catholic University of Korea, Seoul 07345, Korea)

  • Sangduk Hong

    (Department of Otorhinolaryngology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul 06351, Korea)

  • Jae Kwan Jun

    (National Cancer Control Institute, National Cancer Center, Goyang 10408, Korea
    Graduate School of Cancer Science and Policy, National Cancer Center, Goyang 10408, Korea)

Abstract

Alcohol consumption is a major risk factor for head and neck cancer (HNC), yet little data exist examining drinking patterns and HNC risk. In this population-based, retrospective cohort study, 11,737,467 subjects were recruited from the Korean National Health Insurance Service database. The risks of overall HNC and HNC subtypes according to average alcohol consumption, drinking frequency, and daily amount were examined using Cox proportional hazard models. Over the median follow-up of 6.4 years, 15,832 HNC cases were identified. HNC risk linearly increased with drinking frequency ( p -trend < 0.01; adjusted hazard ratio [aHR] 1.55, 95% confidence interval [CI] 1.45–1.67 in subjects who drank 7 days/week). HNC risk also increased according to daily amount of alcohol consumption ( p -trend < 0.01), but plateaued from 5–7 units/occasion (aHR 1.25, 95% CI 1.19–1.31) to >14 units/occasion (aHR 1.26, 95% CI 1.13–1.40). When stratified by average alcohol consumption, drinking frequency, but not daily amount, showed a linear relationship with HNC risk in moderate and heavy drinkers. When comparing the HNC subtypes, similar tendencies were observed in cancers of the oral cavity, pharynx, and larynx, but not in the salivary gland. In conclusion, drinking frequency is a stronger risk factor for HNC, especially for cancer of the oral cavity, pharynx, and larynx, than the daily amount of alcohol consumption.

Suggested Citation

  • Hye Yeon Koo & Kyungdo Han & Dong Wook Shin & Jung Eun Yoo & Mi Hee Cho & Keun Hye Jeon & Dahye Kim & Sangduk Hong & Jae Kwan Jun, 2021. "Alcohol Drinking Pattern and Risk of Head and Neck Cancer: A Nationwide Cohort Study," IJERPH, MDPI, vol. 18(21), pages 1-14, October.
    • Handle: RePEc:gam:jijerp:v:18:y:2021:i:21:p:11204-:d:664452
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    References listed on IDEAS

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    1. Yu Zhang & Ruixia Wang & Limin Miao & Longbiao Zhu & Hongbing Jiang & Hua Yuan, 2015. "Different Levels in Alcohol and Tobacco Consumption in Head and Neck Cancer Patients from 1957 to 2013," PLOS ONE, Public Library of Science, vol. 10(4), pages 1-13, April.
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    Cited by:

    1. Michał Żurek & Kamil Jasak & Karolina Jaros & Piotr Daniel & Kazimierz Niemczyk & Anna Rzepakowska, 2022. "Clinico-Epidemiological Analysis of Most Prevalent Parotid Gland Carcinomas in Poland over a 20-Year Period," IJERPH, MDPI, vol. 19(16), pages 1-15, August.

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