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T1DMicro: A Clinical Risk Calculator for Type 1 Diabetes Related Microvascular Complications

Author

Listed:
  • Paul Minh Huy Tran

    (Center for Biotechnology and Genomic Medicine, Augusta University, 1120, 15th Str., Augusta, GA 30912, USA
    These authors contributed equally to the study.)

  • Eileen Kim

    (Center for Biotechnology and Genomic Medicine, Augusta University, 1120, 15th Str., Augusta, GA 30912, USA)

  • Lynn Kim Hoang Tran

    (Center for Biotechnology and Genomic Medicine, Augusta University, 1120, 15th Str., Augusta, GA 30912, USA)

  • Bin Satter Khaled

    (Center for Biotechnology and Genomic Medicine, Augusta University, 1120, 15th Str., Augusta, GA 30912, USA)

  • Diane Hopkins

    (Center for Biotechnology and Genomic Medicine, Augusta University, 1120, 15th Str., Augusta, GA 30912, USA)

  • Melissa Gardiner

    (Center for Biotechnology and Genomic Medicine, Augusta University, 1120, 15th Str., Augusta, GA 30912, USA)

  • Jennifer Bryant

    (Center for Biotechnology and Genomic Medicine, Augusta University, 1120, 15th Str., Augusta, GA 30912, USA)

  • Risa Bernard

    (Center for Biotechnology and Genomic Medicine, Augusta University, 1120, 15th Str., Augusta, GA 30912, USA)

  • John Morgan

    (Department of Neurology, Medical College of Georgia, Augusta University, 1120, 15th Str., Augusta, GA 30912, USA)

  • Bruce Bode

    (Atlanta Diabetes Associates, Atlanta, GA 30318, USA)

  • John Chip Reed

    (Southeastern Endocrine and Diabetes, Atlanta, GA 30076, USA)

  • Jin-Xiong She

    (Center for Biotechnology and Genomic Medicine, Augusta University, 1120, 15th Str., Augusta, GA 30912, USA
    Department of Obstetrics and Gynecology, Augusta University, 1120, 15th Str., Augusta, GA 30912, USA)

  • Sharad Purohit

    (Center for Biotechnology and Genomic Medicine, Augusta University, 1120, 15th Str., Augusta, GA 30912, USA
    Department of Obstetrics and Gynecology, Augusta University, 1120, 15th Str., Augusta, GA 30912, USA
    Department of Undergraduate Health Professionals, Augusta University, 1120, 15th Str., Augusta, GA 30912, USA
    These authors contributed equally to the study.)

Abstract

Development of complications in type 1 diabetes patients can be reduced by modifying risk factors. We used a cross-sectional cohort of 1646 patients diagnosed with type 1 diabetes (T1D) to develop a clinical risk score for diabetic peripheral neuropathy (DPN), autonomic neuropathy (AN), retinopathy (DR), and nephropathy (DN). Of these patients, 199 (12.1%) had DPN, 63 (3.8%) had AN, 244 (14.9%) had DR, and 88 (5.4%) had DN. We selected five variables to include in each of the four microvascular complications risk models: age, age of T1D diagnosis, duration of T1D, and average systolic blood pressure and HbA1C over the last three clinic visits. These variables were selected for their strong evidence of association with diabetic complications in the literature and because they are modifiable risk factors. We found the optimism-corrected R2 and Harrell’s C statistic were 0.39 and 0.87 for DPN, 0.24 and 0.86 for AN, 0.49 and 0.91 for DR, and 0.22 and 0.83 for DN, respectively. This tool was built to help inform patients of their current risk of microvascular complications and to motivate patients to control their HbA1c and systolic blood pressure in order to reduce their risk of these complications.

Suggested Citation

  • Paul Minh Huy Tran & Eileen Kim & Lynn Kim Hoang Tran & Bin Satter Khaled & Diane Hopkins & Melissa Gardiner & Jennifer Bryant & Risa Bernard & John Morgan & Bruce Bode & John Chip Reed & Jin-Xiong Sh, 2021. "T1DMicro: A Clinical Risk Calculator for Type 1 Diabetes Related Microvascular Complications," IJERPH, MDPI, vol. 18(21), pages 1-12, October.
    • Handle: RePEc:gam:jijerp:v:18:y:2021:i:21:p:11094-:d:661988
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